Gene interactions and pathways from curated databases and text-mining

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IL2 — KLK3

Text-mined interactions from Literome

Abdul et al., Cancer Lett 2000 (Neoplasms, Hormone-Dependent...) : IL-1 decreased while IL-2 increased PSA levels of near-confluent LNCaP cells after 24 h of treatment
Mazmanian et al., Nature 2008 (Colitis...) : Purified PSA administered to animals is required to suppress pro-inflammatory interleukin-17 production by intestinal immune cells and also inhibits in vitro reactions in cell cultures
Li et al., Immunopharmacol Immunotoxicol 2008 (Carcinoma, Ehrlich Tumor) : PSP and PSP + APS could significantly increase the percentage of CD3 ( + ) and CD4 ( + ) T-lymphocytes, the ratio of CD4 ( + ) /CD8 ( + ), and the expression of IL-2/IL-2R in spleen and Bax in tumor tissue, but led to a diminution of Bcl-2 and CDK4 in tumor tissue compared with those of control group
Du et al., Int Immunopharmacol 2012 : APS also could induce CD4 ( + ) T cells to produce IL-4, IL-2 and IFN-? and enhance IFN-? expression of CD8 ( + ) T cells
Tian et al., World J Gastroenterol 2012 : APS could increase IL-1a, IL-2 , IL-6, and TNF-a expression and decrease IL-10 levels