Gene interactions and pathways from curated databases and text-mining

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HSP90AA1 — TCF12

Text-mined interactions from Literome

Cox et al., Mol Pharmacol 2003 : We used signaling by aryl hydrocarbon receptor (AhR), an Hsp90 dependent transcription factor , as a functional probe to study the effects of Hsp90 inhibitors in yeast strains with deletion mutations of individual Hsp90 and p23 cochaperone genes
Andersen et al., Development 2012 : In addition, we show that centrosome position and motility are regulated by LIM homeodomain transcription factor activity, which is specifically required for the development of RB peripheral axons
Chen et al., J Biol Chem 2013 (Colorectal Neoplasms...) : Secreted Heat Shock Protein 90a (HSP90a) Induces Nuclear Factor-?B mediated TCF12 Protein Expression to Down-regulate E-cadherin and to Enhance Colorectal Cancer Cell Migration and Invasion ... This suggests that TCF12 expression is required for secreted HSP90a to enhance CRC cell spreading ... Together, these results suggest that the CD91/IKK/NF-?B signaling cascade is involved in secreted HSP90a induced TCF12 expression, leading to E-cadherin down-regulation and enhanced CRC cell migration/invasion