UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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EFNA1 — LCK

Pathways - manually collected, often from reviews:

NCI Pathway Database EPHA forward signaling: Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
Walker-Daniels et al., Mol Cancer Res 2002, Sharfe et al., J Immunol 2003
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database EPHA forward signaling: Ephrin A1/EPHA1-4 complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
Shamah et al., Cell 2001, Sahin et al., Neuron 2005
Evidence: mutant phenotype, assay, physical interaction