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COA1 — STK11
Text-mined interactions from Literome
Thomson et al., Am J Physiol Endocrinol Metab 2007
(Body Weight) :
The purpose of this study was to determine how the lack of muscle
LKB1 would
affect malonyl-CoA levels and/or fatty-acid oxidation ... Comparing wild-type ( WT ) and skeletal/cardiac muscle-specific LKB1 knockout ( KO ) mice, we found that the 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside ( AICAR ) -stimulated decrease in
malonyl-CoA levels in WT heart and quadriceps muscles was entirely
dependent on the presence of
LKB1 , as was the AICAR induced increase in fatty-acid oxidation in EDL muscles in vitro, since these responses were not observed in KO mice
Za'tara et al., Biochem Pharmacol 2008
:
The two activation modes are complementary since
LKB1/AMPK activation by the
CoA-thioester is fully evident under conditions of excess AMP