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MTX1 — RELA

Text-mined interactions from Literome

Majumdar et al., J Immunol 2001 : We investigated the effects of MTX on NF-kappaB activation induced by TNF in Jurkat cells ... Besides TNF, MTX also suppressed the NF-kappaB activation induced by various other inflammatory stimuli ... A partial reversal of MTX induced NF-kappaB suppression by thymidine and folinic acid indicates the role of the thymidylate synthase pathway also ... Overall, our results clearly demonstrate that MTX suppresses NF-kappaB activation through the release of adenosine, which may contribute to the role of MTX in anti-inflammatory, immunomodulatory, and antiproliferative effects
Yozai et al., J Am Soc Nephrol 2005 (Albuminuria...) : MTX also reduced the high glucose induced NF-kappaB activation in vitro and in vivo
Logan et al., Cancer Chemother Pharmacol 2009 (Mucositis) : Both MTX and 5-FU administration caused histological evidence of tissue damage in the AT as well as changes in tissue expression of NF-kappaB and specific pro-inflammatory cytokines
Chang et al., Anticancer Res 2009 (Liver Neoplasms, Experimental) : The luciferase expression by BLI assay reflected that the TPA induced NF-kappaB activity was suppressed by MTX after 16 h treatment ... BLI directly revealed that MTX inhibited cellular transformation by suppressing NF-kappaB activity