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EDN1 — MAPK12

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El-Mowafy et al., FEBS Lett 1999 : Endothelin-1 (ET-1) , a primary antecedent in coronary heart diseases, enhanced MAPK activity, phosphorylation and nuclear translocation in a concentration-responsive but RSVL-sensitive manner
Ueyama et al., Mol Cell Biochem 1999 (Cardiomegaly) : Endothelin-1 activates p38 mitogen activated protein kinase via endothelin-A receptor in rat myocardial cells
Kawamura et al., Am J Physiol 1999 : We previously reported that endothelin-1 (ET-1) activates p42/p44 mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells and consequently induces synthesis of interleukin-6
Dulin et al., J Biol Chem 2000 (Calcium Signaling) : Both RGS3 and RGS3T bound to endogenous Galpha ( q/11 ) and inhibited endothelin-1 stimulated calcium mobilization and mitogen activated protein kinase activity to a similar extent
Inui et al., Life Sci 2000 : Effect of endothelin-1 ( 1-31 ) on p38 mitogen activated protein kinase in cultured human mesangial cells
Kawanabe et al., Eur J Pharmacol 2001 (Neuroblastoma) : Endothelin-1 activated mitogen activated protein kinase in B103 cells
Kusano et al., Kidney Blood Press Res 2001 : We investigated whether rHuEPO has modulative effects on the endothelin-1 (ET-1) induced elevation of cytosolic free calcium concentration ( [ Ca2+ ] i ) and mitogen activated protein ( MAP ) kinase activation in vascular smooth muscle cells ( VSMC )
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2002 : We previously showed that prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells
Rachdaoui et al., Am J Physiol Endocrinol Metab 2003 : In contrast, activation of p38 MAPK by endothelin-1 was not affected by chronic ethanol exposure
Tokuda et al., Eur J Endocrinol 2003 : We have reported that endothelin-1 (ET-1) activates p38 mitogen activated protein ( MAP ) kinase through protein kinase C in osteoblast-like MC3T3-E1 cells, and that p38 MAP kinase plays a role in the ET-1 induced heat shock protein 27 (HSP27)
Zubkov et al., J Cardiovasc Pharmacol 2004 : The following results were observed : ( 1 ) endothelin-1 produced phosphorylation of MAPK and RhoA and contraction by activation of endothelin-A but not endothelin-B receptors ; ( 2 ) MAPK inhibitors, PD 98059 and U0126, PTK inhibitor, genistein, Src kinase inhibitor, damnacanthal, and Janus tyrosine kinase ( JAK2 ) inhibitor, AG-490, abolished endothelin-1 induced contraction and MAPK immunoreactivity ; ( 3 ) PTK inhibitor, staurosporine, and phosphatidylinositol 3-kinase (PI- 3K) inhibitor wortmannin abolished endothelin-1 induced contraction but not MAPK immunoreactivity ; ( 4 ) Rho-kinase inhibitor, Y-27632, reduced endothelin-1 induced contraction ; ( 5 ) PI-3K inhibitor, wortmannin, but not PKC and PTK inhibitors, reduced endothelin-1 induced RhoA activation ; ( 6 ) endothelin-1 increased the level of myosin light chain ( MLC ) phosphorylation, and Rho-kinase inhibitor, Y-27632, reduced the effect of endothelin- 1 on MLC phosphorylation
Irukayama-Tomobe et al., J Cardiovasc Pharmacol 2004 (Hypertrophy) : Activation of peroxisome proliferator activated receptor-alpha decreases endothelin-1 induced p38 mitogen activated protein kinase activation in cardiomyocytes
Patzak et al., Am J Physiol Regul Integr Comp Physiol 2007 : However, phosphorylation of p38 MAPK induced by norepinephrine or endothelin-1 was reduced in vessels treated with Ado, whereas 20-kDa myosin light chain was unchanged
Nilsson et al., Eur J Pharmacol 2008 (Cardiovascular Diseases) : We hypothesize that protein kinase C ( PKC ) and mitogen activated kinases ( MAPK ) are involved in the regulation of endothelin receptors
Eriksson et al., J Ethnopharmacol 2008 : We also demonstrate that Panax ginseng, endothelin-3 (ET-3) and alpha-melanocyte stimulating hormone ( MSH ) stimulate an activation of mitogen activated protein kinase ( MAPK )
Nilsson et al., BMC cardiovascular disorders 2008 : The involvement of PKC and MAPK in the endothelin receptor regulation was examined by culture in the presence of antagonists
Chen et al., BMC cell biology 2009 : Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells
Sandhu et al., Toxicol Appl Pharmacol 2010 : The present study was designed to examine if lipid-soluble ( dimethyl sulfoxide-soluble ) cigarette smoke particles ( DSP ) induces upregulation of contractile endothelin type B ( ET ( B ) ) receptors in rat cerebral arteries and if activation of mitogen activated protein kinase ( MAPK ) and nuclear factor-kappaB ( NF-?B ) mediate the upregulation of contractile endothelin receptors in the cerebral arteries
Zhang et al., TheScientificWorldJournal 2010 (Cardiovascular Diseases...) : Up-regulation of endothelin receptors induced by cigarette smoke -- involvement of MAPK in vascular and airway hyper-reactivity
Rajapurohitam et al., Mol Cell Biochem 2012 (Hypertrophy) : In addition, NF-?B inhibition significantly attenuated angiotensin II and endothelin-1 induced p38 MAPK activation whereas inhibition of p38 MAPK blocked both angiotensin II- and endothelin-1 induced increases in leptin secretion
Peng et al., Pflugers Arch 2012 : N-Acetyl-seryl-aspartyl-lysyl-proline ( Ac-SDKP ) inhibits endothelin-1 (ET-1) induced activation of p44/42 mitogen activated protein kinase ( p44/42 MAPK ) and collagen production in cultured rat cardiac fibroblasts ( RCFs )
Lazou et al., Circ Res 1994 : In isolated myocytes, endothelin 1 ( 100 nmol/L for 5 minutes ) also stimulated MAPK , but stimulation by norepinephrine or isoproterenol was difficult to detect ... In isolated myocytes, endothelin 1 ( 100 nmol/L for 5 minutes ) also stimulated MAPK , but stimulation by norepinephrine or isoproterenol was difficult to detect
Sugimoto et al., Biochem Biophys Res Commun 1993 : Atrial natriuretic peptide inhibits endothelin-1 induced activation of mitogen activated protein kinase in cultured rat mesangial cells ... In cultured rat glomerular mesangial cells, endothelin-1 (ET-1) activated both pp 44 and pp 42 mitogen activated protein ( MAP ) kinases ... In cultured rat glomerular mesangial cells, endothelin-1 (ET-1) activated both pp 44 and pp 42 mitogen activated protein ( MAP ) kinases
Sugimoto et al., J Diabetes Complications 1995 : Cyclic nucleotides attenuate endothelin-1 induced activation of mitogen activated protein kinase in cultured rat mesangial cells
Schramek et al., J Cardiovasc Pharmacol 1995 : To evaluate a possible mechanism for the chronic regulation of MAPK/ERK kinase-1 (MEK-1) and p42 mitogen activated protein kinase ( MAPK ) we studied the long-term effects of the G-protein coupled receptor agonist endothelin-1 (ET-1) and the protein tyrosine kinase coupled receptor agonist platelet derived growth factor BB ( PDGF BB ) on MEK-1 and p42 MAPK in glomerular mesangial cells ( GMCs )
Jones et al., Life Sci 1996 : Effects of endothelin on mitogen activated protein kinase activity and protein synthesis in isolated adult feline cardiac myocytes
Guo et al., Hypertens Res 1996 : Inhibitory effect of BQ-123 on endothelin-1 stimulated mitogen activated protein kinase and cell growth of rat vascular smooth muscle cells
Scott et al., Biochem J 1996 : In bovine airway smooth-muscle cells platelet derived growth factor ( PDGF ) and endothelin ( Et-1 ) stimulate sustained and comparable activation of mitogen activated protein kinase ( MAP kinase ) but display very different mitogenic efficacies, with PDGF inducing 50 times more DNA synthesis than Et-1
Buist et al., Biochem Biophys Res Commun 1998 (Neuroectodermal Tumors, Primitive, Peripheral) : Lysophosphatidic acid (LPA) and endothelin-1 (ET-1) , two ligands for G-protein coupled receptors ( GPCRs ), induce activation of mitogen activated protein kinase ( MAPK )
Dulin et al., Mol Cell Biol 1999 : A role of RGS3 in postreceptor signaling was demonstrated by decreased calcium responses and mitogen activated protein ( MAP ) kinase activity induced by endothelin-1 in HMC stably overexpressing RGS3
Kimura et al., Endocrinology 1999 : The regulation of mitogen activated protein ( MAP ) kinase by endothelin-1 (ET-1) in cultured rat puerperal uterine myometrial cells was investigated