◀ Back to CD4

CD4 — IFIT1

Text-mined interactions from Literome

Van Drenth et al., J Immunol 2000 : Using murine T cell hybridomas transfected to express native or mutated forms of CD4, it was determined that IL-16/CD4 induces a p56 ( lck ) -dependent inhibitory signal for CXCR4, which is independent of its tyrosine catalytic activity
Sorice et al., Glycoconj J 2000 : The immunoprecipitation with anti-GM3 revealed the presence of a 58kDa band immunostained with anti-CD4 Ab, suggesting that the GM3-CD4 interaction does not require its association with p56Ick
Mazerolles et al., J Immunol 1996 : Phosphatidylinositol 3-kinase participates in p56 ( lck ) /CD4 dependent down-regulation of LFA-1 mediated T cell adhesion ... Here we show that binding of these ligands to CD4 induced the activation of the tyrosine kinase p56 ( lck ) associated with CD4 and also the lipid kinase phosphatidylinositol-3 kinase ( PI3-kinase ) associated with the CD4-p56 ( lck ) complex in the HUT78 cell line
Cruikshank et al., J Immunol 1996 : The binding of IL-16 to CD4 results in activation of p56 ( lck ), whose adaptor function is essential for the chemotactic response
Kaneko et al., Clin Exp Immunol 1997 (HIV Infections) : On the other hand, inhibition of the mixed lymphocyte reaction (MLR) in CD4+ T cells by gp120, which may be related to gp120 mediated down-regulation of CD4 expression on T cells and activation of protein tyrosine kinase p56 ( lck ) in CD4+ T cells, was observed even in the absence of macrophage derived TNF-alpha induced by gp120
Moutouh et al., J Virol 1998 (HIV Infections) : These observations demonstrate that CD4 signaling mediates HIV induced apoptosis by a mechanism independent of Fas-Fas ligand interaction, does not require p56 ( lck ) signaling, and may involve a critical region for CD4 dimerization