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PIK3CA — TP53
Text-mined interactions from Literome
Bar et al., Cell Death Differ 2005
:
The
PI3K inhibitor LY294002
prevents p53 induction by DNA damage and attenuates chemotherapy induced apoptosis ... These findings invoke an unexpected positive
role for
PI3K in
p53 activation by anticancer agents, and suggest that the efficacy of PI3K inhibitors in cancer therapy may be greatly affected by the tumor p53 status
Kim et al., Mol Cell Biol 2007
(Cell Transformation, Neoplastic) :
Next, we tested whether oncogenic
PIK3CA , like inactivated PTEN, could
activate p53 ... Retroviral expression of oncogenic human
PIK3CA in MCF10A cells
led to activation of
p53 and upregulation of p53 regulated genes ... Finally, targeted deletion of an endogenous allele of oncogenic, but not wild-type,
PIK3CA in a human cancer cell line
led to a reduction in
p53 levels and a decrease in the expression of p53 regulated genes
Filiz et al., Int J Biochem Cell Biol 2008
:
Furthermore, CQ inhibited H2O2 mediated up-regulation of
p53 activity in the M17 cells and this was
dependent on
PI3K activation
Astanehe et al., J Cell Sci 2008
(Carcinoma...) :
Mechanisms underlying
p53 regulation of
PIK3CA transcription in ovarian surface epithelium and in ovarian cancer ... Conditional suppression of functional
p53 increased
p110alpha transcripts, protein levels and PI3K activity in immortalized, non-tumorigenic ovarian surface epithelial ( OSE ) cells, the precursors of ovarian carcinoma ... Conversely, overexpression of
p53 by adenoviral infection and
activation of p53 by gamma-irradiation both diminished
p110alpha protein levels in normal OSE and ovarian cancer cells
Kok et al., Trends Biochem Sci 2009
(Neoplasms) :
Recently identified mechanisms that control PI3K production include increased gene copy number in cancer, and transcriptional
regulation of the p110alpha
PI3K gene by FOXO3a, NF-kappaB and
p53 , and of the PI3K regulatory subunits by STAT3, EBNA-2 and SREBP
Li et al., Cancer Lett 2009
(Adenocarcinoma...) :
Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit
PI3K/Akt signaling and thereby
regulate p53 activation
Zhou et al., Cell Mol Immunol 2009
:
PI3K/AKT mediated
p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis
Zhang et al., Int J Radiat Oncol Biol Phys 2012
(Lung Injury...) :
Apoptosis correlated with increased PTEN expression,
inhibition of downstream
PI3K/AKT signaling, and increased
p53 and Bax protein levels
Habib et al., Genes & cancer 2011
:
These novel data provide evidence that loss of TSC-2, PTEN, and
p53 as well as
activation of
PI 3-K and mTOR is associated with kidney cancer in the Eker rat, while sustained expression of TSC-2, PTEN, and p53 may prevent progression of kidney cancer in TSC patients
Bhowmick et al., J Virol 2013
(Rotavirus Infections) :
This function of NSP1 was independent of its interferon or phosphatidylinositol 3-kinase (PI3K)/AKT modulation activity since
p53 degradation was observed in Vero cells as well as in the
presence of
PI3K inhibitor
Chou et al., Toxicol In Vitro 2013
:
A specific
PI3K inhibitor
attenuated the UVB induced ERK1/2 and
p53 phosphorylation