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POLDIP2 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sanchez-Prieto et al., Cancer Res 2000
:
In this study, we have found that the
p38 mitogen activated protein kinase ( MAPK )
plays a key role in the activation of
p53 by genotoxic stress when provoked by chemotherapeutic agents
Kwon et al., J Biol Chem 2002
:
MC induced p38 MAPK activation in p53 expressing cells but not in p53-deficient cells, indicating that the
p38 MAPK activation was
dependent on early
p53 activation
de la Monte et al., J Alzheimers Dis 2000
:
H2O2-treatment resulted in dose dependent increases in cell death due to genomic and mitochondrial DNA damage associated with increased levels of 8-OHdG and the
p53 and CD95 pro-apoptosis genes, reduced levels of the Bcl-2 survival gene,
activation of JNK and
p38 stress kinases, and inhibition of PI3 kinase survival signaling
Bulavin et al., Mol Cell Biol 2003
(MAP Kinase Signaling System) :
Inhibition of
p38 mitogen activated protein kinase ( MAPK ) activation correlated with the deregulation of p53 activation, and both a p38 MAPK chemical inhibitor and the expression of a dominant negative p38alpha
inhibited p53 activation in the presence of H-ras in wild-type MEF
Kim et al., Arch Biochem Biophys 2005
(Carcinoma, Hepatocellular) :
Furthermore,
p53 mediated apoptotic activity in BaP treated cells was
inhibited by
p38 kinase inhibitor
Roobol et al., Biochem J 2011
(Hypothermia) :
In addition, we show that although
p38MAPK ( p38 mitogen activated protein kinase ) is also
involved in activation of
p53 upon mild hypothermia, this is probably the result of activation of p38MAPK by ATR
Furlan et al., J Hepatol 2012
:
We investigated the mechanism leading to p53 regulation by Met and found that Abl and
p38MAPK are
required for
p53 phosphorylation on S ( 389 ), Mdm2 upregulation, and hepatocyte survival
Santoro et al., Carcinogenesis 2013
(Cell Transformation, Neoplastic) :
Since melatonin induced
p53 phosphorylation requires an intact p38 phosphorylation cascade and
p38 can be
activated by G proteins, we supposed that melatonin 's activities could be mediated by its G-protein coupled membrane receptors, MT1 and MT2