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CBFA2T2 — SRC

Text-mined interactions from Literome

Hakak et al., Oncogene 2000 : Activation of PI3-kinase by v-Src may be mediated by the association of the adapter protein Cbl with the p85 subunit
Beauséjour et al., Apoptosis 2012 : We report that : ( 1 ) the predominant PI3-K complexes expressed by HIEC cells are p110a/p85ß and p110a/p55? ; ( 2 ) the inhibition and/or siRNA mediated expression silencing of p110a, but not that of p110ß, ? or d, results in Akt-1 down-activation and consequent apoptosis ; ( 3 ) the expression silencing of p85ß or p55?, but not that of p85a, likewise induces Akt-1 down-activation and apoptosis ; however, the impact of a loss of p55? on both Akt-1 activation and cell survival is significantly greater than that from the loss of p85ß ; and ( 4 ) both the p110a/p85ß and p110a/p55? complexes are engaged by ß1 integrin/Fak/Src signaling ; however, the engagement of p110a/p85ß is primarily Src dependent, whereas that of p110a/p55? is primarily Fak dependent ( but Src independent )
Arcaroli et al., Clin Cancer Res 2012 (Colorectal Neoplasms) : Importantly, we show that Src inhibition reduces the interaction between Src and p85 , subsequently decreasing Akt dependent signaling