◀ Back to VEGFA
CDH5 — VEGFA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CDH5
→
VEGFA
(increases)
Evidence: VEGF increases phosphorylation of VE-cadherin, the major component of endothelial intercellular adherens junctions, and of the tight junction proteins occludin and zonula occludens-1
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NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer)/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-CDH5-CTNNB1-CTNNA1)
→
VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer)/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-CDH5-CTNNB1-CTNNA1)
→
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
(modification, collaborate)
Carmeliet et al., Cell 1999
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
IQGAP1 (IQGAP1)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
Text-mined interactions from Literome
Rahimi et al., Mol Biol Cell 1999
:
A
role for
cadherin-5 in regulation of
vascular endothelial growth factor receptor 2 activity in endothelial cells
Lin et al., Mol Pharmacol 2003
:
Of interest, resveratrol, at the dose of 1 or 2.5 muM, effectively abrogated
VEGF mediated tyrosine phosphorylation of
vascular endothelial (VE)-cadherin and its complex partner, beta-catenin ... In addition, antioxidant N-acetyl-cysteine was demonstrated to strongly inhibit
VEGF mediated Src activation,
VE-cadherin tyrosine phosphorylation, and HUVEC tube formation
Lambeng et al., Circ Res 2005
:
In this model, Src inhibition impaired
VEGF induced
VE-cadherin phosphorylation, indicating that VE-cadherin phosphorylation was dependent on Src activation
Chang et al., Placenta 2005
:
Induction of
VE-cadherin in rat placental trophoblasts by
VEGF through a NO-dependent pathway ... In explant culture,
VEGF ( 0.01-1.0 ng/ml )
increased the protein abundance of
VE-cadherin
Sulkowska et al., Tumori 2006
(Adenocarcinoma...) :
Levels of
VE-cadherin increase independently of
VEGF in preoperative sera of patients with colorectal cancer
Wallez et al., Oncogene 2007
:
Src kinase phosphorylates
vascular endothelial-cadherin in
response to
vascular endothelial growth factor : identification of tyrosine 685 as the unique target site
Ali et al., J Pharmacol Sci 2006
:
The novel Src kinase inhibitor M475271 inhibits
VEGF induced
vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association ... The findings reveal pretreatment with M475271 significantly inhibits
VEGF induced
VE-cadherin and beta-catenin phosphorylation
Villasante et al., J Clin Endocrinol Metab 2007
(Ovarian Hyperstimulation Syndrome) :
Culturing of HUVEC with high doses of E2 produced no significant changes in VE-cadherin concentration, but hCG and
VEGF produced a significant
increase in
VE-cadherin release
Dalyot-Herman et al., Biochem Pharmacol 2009
:
It did, however, inhibit
VEGF induced phosphorylation of
VE-cadherin and reduce the association of beta-catenin with VE-cadherin
Frank et al., Cancer Res 2011
(Melanoma...) :
In vitro,
VEGF induced the expression of
CD144 in ABCB5 ( + ) subpopulations that constitutively expressed VEGFR-1 but not in ABCB5 ( - ) bulk populations that were predominantly VEGFR-1 ( - )
Chung et al., J Mol Med (Berl) 2013
(Neoplasms...) :
Here, we show that CAPE suppressed
VEGF induced proliferation, tube formation, migration, the formation of actin stress fibers and loss of
VE-cadherin at cell-cell contacts in endothelial cells, indicating the inhibition of VEGF mediated VEGF receptor-2 (VEGFR-2) and its downstream signal activation in vitro
Zang et al., Cell Signal 2013
:
Aberrant association between vascular endothelial growth factor receptor-2 and
VE-cadherin in
response to
vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
Rapraeger et al., FEBS J 2013
:
We find that the Sdc1 coupled ternary receptor complex is required for
VEGF signalling and for
stimulation of vascular endothelial cell migration by
vascular endothelial cadherin ( VE-cadherin ) engagement
Herr et al., Fertil Steril 2013
:
This down-regulation was associated with changed rates of vascular permeability : hCG induced a
VEGFA dependent down-regulation of
VE-cadherin , nectin 2, and claudin 5, which increased the endothelial permeability in the coculture system
Hayashi et al., Nature communications 2013
:
We conclude that the role of Tie2 in maintenance of vascular quiescence involves VE-PTP dependent dephosphorylation of VEGF receptor-2, and that
VEGF receptor-2 activity
regulates VE-cadherin tyrosine phosphorylation, endothelial cell polarity and lumen formation
Hebda et al., Cell communication and signaling : CCS 2013
:
In this context, we have previously characterized that
VEGF ( vascular endothelial growth factor )
leads to
VE-cadherin phosphorylation, ß-arrestin2 recruitment and VE-cadherin internalization in mouse endothelial cells