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HDAC7 — VEGFA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Wang et al., Proc Natl Acad Sci U S A 2008
:
We show that VEGF induces the phosphorylation of three conserved serine residues in histone deacetylase 7 (HDAC7) via protein kinase D, which promotes nuclear export of
HDAC7 and
activation of
VEGF-responsive genes in ECs
Ha et al., Arterioscler Thromb Vasc Biol 2008
:
VEGF stimulates
HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis ... Here, we investigated the
role of
HDAC7 in
vascular endothelial growth factor ( VEGF ) signaling and angiogenesis ... We show for the first time that
VEGF stimulated phosphorylation of
HDAC7 at the sites of Ser178, Ser344, and Ser479 in a dose- and time dependent manner, which leads to the cytoplasmic accumulation of HDAC7 ... Our results demonstrate that
VEGF stimulates PKD1 dependent
HDAC7 phosphorylation and cytoplasmic accumulation in endothelial cells modulating gene expression and angiogenesis
Margariti et al., Circ Res 2010
(Hypertrophy) :
Moreover,
vascular endothelial growth factor stimulation
suppressed the binding of
HDAC7 with beta-catenin, disrupting the complex and releasing beta-catenin to translocate into the nucleus
Su et al., Mol Cell Biol 2013
:
Inhibition of protein kinase C ( PKC ) blocks
VEGF induced ubiquitination of FLNB and its interaction with
HDAC7 ... Small interfering RNA ( siRNA ) knockdown of FLNB or ubiquitin ( Ub ) in human primary endothelial cells blocks
VEGF mediated cytoplasmic accumulation of
HDAC7 , reduces VEGF induced expression of the HDAC7 target genes Mmp-10 and Nur77, and inhibits VEGF induced vascular permeability