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IFNG — VEGFA
Text-mined interactions from Literome
Kawano et al., Am J Reprod Immunol 2000
:
Effects of
interferon-gamma on secretion of
vascular endothelial growth factor by endometrial stromal cells ... The aim of this study was to clarify the physiological
effects of
interferon (IFN)-gamma on secretion of
vascular endothelial growth factor ( VEGF ) by endometrial stromal ( ES ) cells ... The
effects of
IFN-gamma on production of
VEGF by ES cells were examined by analyzing VEGF mRNA expression with Northern blotting analysis and by assaying VEGF protein
Trompezinski et al., Exp Dermatol 2002
:
In HF, the basal level of
VEGF secretion was
reduced by
IFN-gamma and slightly increased by IL-4 whereas in HK, IFN-gamma enhanced the secretion of VEGF after 48 h and IL-4 either tended to reduce VEGF secretion or did not exert any effect ... Taken together, these results indicate opposite
effects of
IFN-gamma and IL-4 on
VEGF expression from normal and activated HF and HK
Choi et al., Am J Reprod Immunol 2002
:
These results suggest that IL-1beta,
IFN-gamma , and TNF-alpha may
regulate the production of
VEGF in early gestational trophoblasts
Ramanathan et al., Experimental biology and medicine (Maywood, N.J.) 2003
(Anoxia) :
Interferon-gamma (IFN-gamma) with Escherichia coli lipopolysaccharide (LPS) also
upregulates expression of
VEGF , as well as of the inducible nitric oxide synthase (iNOS) ... However, the iNOS inhibitor aminoguanidine ( AG ) decreases the
VEGF expression
induced by
LPS/IFN-gamma , indicating an important role for NO ...
LPS/IFN-gamma treatment
induces minimal
VEGF protein expression in macrophages cultured at low cell densities ( < 0.25 x 10 ( 6 ) cells/cm ( 2 ) ) ; at higher cell densities ( > 0.25 x 10 ( 6 ) cells/cm ( 2 ) ) that lead to conditions of pericellular hypoxia, however, induction of VEGF expression was strong ... Transient transfection of RAW 264.7 cells with luciferase reporter constructs of the murine VEGF promoter indicates that both hypoxia and
LPS/IFN-gamma independently
induce VEGF promoter activity, irrespective of cell density ... Although
LPS/IFN-gamma treatment
induces transcriptional activation of the
VEGF promoter, significant levels of VEGF protein are only expressed by cells at high density under conditions of pericellular hypoxia ... Deletion analysis of the VEGF promoter shows that the hypoxia response element region and its immediate flanking sequences are essential for both hypoxia and
LPS/IFN-gamma induced
VEGF promoter activation
Mor et al., J Immunol 2004
(Anoxia...) :
Indeed,
VEGF augmented
IFN-gamma and inhibited IL-10 secretion by T cells responding to mitogen or Ag ; thus, VEGF can enhance a Th1 phenotype
Malaguarnera et al., Int Immunopharmacol 2005
:
Moreover, co-stimulation of PRL with LPS caused activation of HMMs functions, enhancement of HO-1 expression and induction of VEGF release, whereas addition of PRL inhibited up-regulation of HO-1 or
VEGF induced by
IFN-gamma or TNF-alpha
Battle et al., Cancer Res 2006
:
IFN-gamma blocks the biological activity of
VEGF through inhibition of genes necessary for the VEGF response, including angiopoietin-2, urokinase plasminogen activator, tissue inhibitor of matrix metalloproteinase-1, cyclooxygenase-2, and VEGF receptor 2
Cudmore et al., Circulation 2007
(Pre-Eclampsia) :
Adenoviral overexpression of HO-1 in endothelial cells inhibited
VEGF mediated sFlt-1 release and
interferon-gamma- and tumor necrosis factor-alpha induced sEng release, whereas HO-1 inhibition potentiated sFlt-1 and sEng production from endothelial cells and placental villous explants
Jeon et al., Mol Cells 2007
:
IFN-gamma , a potent cytokine,
stimulated VEGF expression only in part through the PKA-CREB pathway
Ray et al., EMBO J 2007
:
Although
IFN-gamma induced persistent
VEGF-A mRNA expression, translation was suppressed by delayed binding of the GAIT complex to a specific element delineated in the 3'UTR
Chen et al., Microcirculation 2008
(Dermatitis, Atopic...) :
IL-6 and
IFN-gamma stimulated
VEGF-A mRNA production in the skin and in primary keratinocytes of transgenic mice ... In conclusion, IL-6 and
IFN-gamma may
play important roles in upregulation of
VEGF-A , along with other pro-angiogenic factors, to induce dermal microvascular angiogenesis
Kommineni et al., Biochem Biophys Res Commun 2008
(Corneal Neovascularization) :
TNF-alpha and IL-1 induced
VEGF-A secretion by corneal fibroblasts ( HCRF ) and this was
inhibited significantly by
IFN-gamma ...
IFN-gamma inhibited TGF-beta
induced VEGF-A secretion but not sVEGF-R1 secretion ... This is the first report demonstrating the inhibitory and stimulatory
effects of
IFN-gamma on
VEGF-A and sFlt-1 secretion, respectively
Sow et al., Dev Comp Immunol 2009
(Respiratory Distress Syndrome, Newborn...) :
We report that
VEGF induced the expression of chemokines ( IL-8, RANTES, MCP-1 ), cytokines (
IFN-gamma , IL-6, TNF-alpha, GMCSF ), Toll-like receptor (TLR)-4, complement family members ( C3, CFB, CFH ) and collectins ( SP-A, SP-D )
Bordin et al., Int J Oral Maxillofac Implants 2009
(Periodontitis) :
Fibroblasts stimulated with TNF alpha showed increased levels of IL6, IL8, MCP1 ; neutrophil chemokine growth related oncogene alpha stimulation with
IFN gamma increased MCP1 ; and stimulation with IL4
increased VEGF
Liu et al., Molecular vision 2010
:
IFNgamma promoted human
VEGF expression in both adult and fetal RPE cells ... The PI-3K/Akt/mTOR/p70 S6 kinase pathway is required for
IFNgamma induced
VEGF expression in retinal cells ... We provide evidence that
IFNgamma induces
VEGF expression in human retinal pigment epithelial cells ... Our work emphasizes that the activation of the PI-3K/mTOR/translational pathway is important for
IFNgamma mediated
VEGF expression in RPE cells
Gullick et al., PloS one 2010
(Arthritis, Rheumatoid...) :
Finally, IL-17, but not
IFNgamma ,
increased VEGF-A production by RA synovial fibroblasts in vitro
Xiong et al., Am J Pathol 1998
:
In RAW cells, Ng-nitro-L-arginine-methyl ester and AG block
IFNgamma/LPS activated , but not constitutive,
VEGF production, whereas in MPMs, neither constitutive nor IFNgamma/LPS activated VEGF synthesis is affected
Dias et al., Int J Cancer 1998
(Mammary Neoplasms, Experimental...) :
IFN-gamma reduced tumor cell production of
VEGF over a 24-hr period in vitro, suggesting that IL-12 induced IFN-gamma may be responsible for the decline in VEGF levels in vivo