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IFNG — JAK3

Text-mined interactions from Literome

Li et al., Oncogene 1999 : Here we show that expression of the ` malignant ' HPV-18 E6 in human HT1080 cells results in inhibition of Jak-STAT activation in response to IFN-alpha but not IFN-gamma
Nguyen et al., Biochem J 2000 : Here, we report that IFN-alpha/beta and IFN-gamma rapidly activate the JAK-STAT1 ( Janus kinase-signal transducer and activator transcription factor 1 ) and p42/44 mitogen activated protein kinase ( p42/44 MAPK ) in freshly isolated rat hepatocytes
Cottet et al., J Biol Chem 2001 (Diabetes Mellitus, Type 1) : SOCS-1 protein prevents Janus Kinase/STAT dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma
Kim et al., Mol Pharmacol 2001 : These effects inhibit full activation of the IFN-gamma induced Janus kinase ( JAK ) /STAT signaling pathway in FRTL-5 thyroid cells
Hu et al., J Immunol 2003 : We investigated whether GCs could also block activation of Janus kinase-STAT signaling by IFN-gamma , a potent proinflammatory cytokine
Imai et al., FEMS Immunol Med Microbiol 2003 : Mycobacterium bovis bacillus Calmette-Guérin infection promotes SOCS induction and inhibits IFN-gamma stimulated JAK/STAT signaling in J774 macrophages
Huang et al., Mol Pharmacol 2004 : LPS activated p38 mitogen activated protein kinase ( MAPK ), whereas IFNgamma activated Janus kinase and signal transducer and activator of transcription-1 ( STAT1 )
Choi et al., Biochem Biophys Res Commun 2005 (Inflammation) : Anti-inflammatory roles of retinoic acid in rat brain astrocytes : Suppression of interferon-gamma induced JAK/STAT phosphorylation ... Both RA isoforms also reduced IFN-gamma induced activation of signal transducers and activators of transcription ( STAT ) 1, STAT3, Janus kinase (JAK)1, and JAK2
Kaur et al., J Neurochem 2005 : Treatment of neurons with H ( 2 ) O ( 2 ) and rotenone also inhibited interferon-gamma mediated activation of Jak/STAT1
Ehrhart et al., Journal of neuroinflammation 2005 : In addition, this CB2 agonist markedly inhibited IFN-gamma induced phosphorylation of JAK/STAT1
Steiner et al., J Cell Sci 2006 (Lung Neoplasms) : Summarizing, we identify MVP as an IFN-gamma-responsive gene interfering with IFN-gamma activated JAK/STAT signals
Brzózka et al., J Virol 2006 : We here show that RV P in addition is responsible for preventing IFN-alpha/beta- and IFN-gamma stimulated JAK-STAT signaling in RV-infected cells by the retention of activated STATs in the cytoplasm
Nagineni et al., J Cell Physiol 2007 : JAK inhibitor selectively inhibited IFN-gamma induced TGF-beta1 secretion and mRNA levels while reversing the inhibitory effects of IFN-gamma on TGF-beta2
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin induced phosphorylation of JAK2 and ERK, whereas IFN-gamma induced phosphorylation of JAK1, JAK2 , and p38 MAPK ... Prolactin modestly or IFN-gamma greatly induced tyrosine phosphorylation of STAT1, and both were suppressed by JAK inhibitor
Vidy et al., J Virol 2007 : Rabies virus P protein inhibits alpha interferon ( IFN-alpha ) - and IFN-gamma stimulated Jak-STAT signaling by retaining phosphorylated STAT1 in the cytoplasm
Park et al., Mol Immunol 2007 (MAP Kinase Signaling System) : We have shown previously that TGF-beta1 inhibits Th1 development by inhibiting IFN-gamma 's induction of T-bet and other Th1 differentiation genes, and that TGF-beta1 inhibits receptor-proximal IFN-gamma-Jak-Stat signaling responses
Watling et al., Proc Natl Acad Sci U S A 2008 (Neoplasms) : JAK/STAT signaling is not, however, sufficient for a full IFN-gamma response
Whiteman et al., Journal of inflammation (London, England) 2008 : This differential effect on HRV-14 receptor isoforms appears to be related to a combination of decreased IFN-gamma induced JAK-STAT signalling and proteolytic receptor cleavage of the membranous form in IFN-gamma biased HRV-14 infected cells
Panzer et al., Nephrol Dial Transplant 2008 (Glomerulonephritis) : Combined results from EMSA and western blot analysis revealed the inhibitory ability of 15d-PGJ ( 2 ), but not of synthetic PPARgamma ligands, on IFN-gamma induced tyrosine phosphorylation of JAK1, JAK2 , STAT1 and nuclear STAT1 translocation and DNA binding
Gira et al., J Invest Dermatol 2009 (Anoxia) : Iron chelators and hypoxia mimetics inhibit IFNgamma mediated Jak-STAT signaling
Kar et al., Eur J Immunol 2009 (Disease Models, Animal...) : DNA binding as well as silencing experiments revealed the requirement of IFN-gamma mediated JAK-STAT activation even though cystatin did not modulate this signaling cascade by itself
Wu et al., Br J Pharmacol 2009 : Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Park et al., Mol Cells 2010 : These results indicate that JAK/Stat1 mediated IFN-gamma signaling antagonizes TGF-beta1 induced GL alpha transcription, mainly through deprivation of p300 from Smad3, resulting in decreased IgA synthesis
Valmas et al., PLoS Pathog 2010 (Hemorrhagic Fever, Ebola...) : Global loss of STAT and Jak tyrosine phosphorylation in response to both IFNalpha/beta and IFNgamma is reminiscent of the phenotype seen in Jak1-null cells
Lin et al., Arthritis Rheum 2010 (Arthritis, Experimental) : In vivo, WYE-151650 inhibited JAK-3 mediated IL-2 induced interferon-gamma production and decreased the natural killer cell population in mice, while not affecting IL-22 induced serum amyloid A production or EPO induced reticulocytosis
Musso et al., J Exp Med 1995 : In contrast, JAK3 expression was strongly induced during activation by interferon gamma (IFN-gamma) or lipopolysaccharide
Panek et al., J Immunol 1995 : TGF-beta suppression of IFN-gamma induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2 , or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression
Kohlhuber et al., Mol Cell Biol 1997 : Conversely, a JAK1-JAK2 chimera with the amino-terminal domains of JAK1 linked to the pseudokinase and kinase domains of JAK2 is capable of reconstituting JAK-STAT signalling in response to IFN-alpha and -gamma in mutant U4C cells lacking JAK1
Aragane et al., Proc Natl Acad Sci U S A 1997 : STAT1 is a cytoplasmic transcription factor that is phosphorylated by Janus kinases ( Jak ) in response to interferon-gamma (IFNgamma)
Lee et al., Infect Immun 1998 : To test whether ehrlichial infection disrupts Janus kinase ( Jak ) and signal transducer and activator of transcription ( Stat ) signaling induced by IFN-gamma , tyrosine phosphorylation of Stat1, Jak1, and Jak2 in E. chaffeensis infected THP-1 cells was examined by immunoprecipitation followed by immunoblot analysis ... These results suggest that E. chaffeensis blocks IFN-gamma induced tyrosine phosphorylation of Jak and Stat through raising PKA activity in THP-1 cells, which may be an important survival mechanism of ehrlichiae within the host cell