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ACVR1 — SLC22A3

Text-mined interactions from Literome

Desgrosellier et al., Dev Biol 2005 : Here, we demonstrate that ALK2 is sufficient to induce EMT in the heart ... Misexpression of constitutively active ( ca ) ALK2 in non transforming ventricular endocardial cells induced EMT, while caALK5 did not, thus demonstrating that ALK2 activity alone is sufficient to stimulate EMT ... These data suggest that ALK2 activation may stimulate EMT in the AV cushion and that Smad6 may act downstream of ALK2 to negatively regulate EMT
Townsend et al., Cell Signal 2012 : Targeting of specific ALKs by siRNA revealed that TGFßR3 mediated EMT requires ALK2 and ALK3, in addition to ALK5, but not ALK4 or ALK6