◀ Back to BCR
BCR — STAT3
Text-mined interactions from Literome
Spiekermann et al., Exp Hematol 2002
(Cell Transformation, Neoplastic...) :
Stable transfection of BA/F3 cells with TEL-JAK2, TEL-ABL, and BCR-ABL resulted in IL-3 independent growth and strong
activation of
STAT3 and STAT5 by TEL-JAK2 and TEL-ABL, but not by
BCR-ABL
Coppo et al., Oncogene 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Constitutive and specific
activation of
STAT3 by
BCR-ABL in embryonic stem cells
Nakamura et al., Oncogene 2005
(Cell Transformation, Neoplastic...) :
These results indicate that MEKK1 plays a key role in
Bcr-Abl induced
STAT3 activation and in ES cells ' capacity for LIF independent self-renewal, and may thus be involved in Bcr-Abl mediated leukemogenesis in stem cells
Coppo et al., Br J Haematol 2006
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
BCR-ABL activates
STAT3 via JAK and MEK pathways in human cells ... Using BCR-ABL mutants, it was shown that
BCR-ABL tyrosine kinase activity and its Tyr177 residue were
necessary for
STAT3 Ser727 phosphorylation ... Inhibition of BCR-ABL with imatinib mesylate led to a dose dependent downregulation of total STAT3 protein and mRNA, suggesting that
BCR-ABL is
involved in the transcriptional regulation of
STAT3
Otero et al., J Immunol 2006
:
Importantly, STAT3 ( -/- ) B-1 cells become susceptible to irradiation, indicating that
STAT3 activation by the
BCR in the presence of IL costimuli account for the inherent radioresistance of peritoneal B-1 B cells
Wang et al., Oncogene 2007
:
In an electrophoretic mobility shift assay,
BCR stimulation
led to enhanced DNA binding of the
STAT3 in DT40, but not in the Lyn-null cells
Coppo et al., Cell Signal 2009
:
To better understand the behavior of BCR-ABL in pluripotent stem cells, we previously developed a murine embryonic stem ( ES ) cell model transformed by p210-BCR-ABL and reported that
BCR-ABL activates
STAT3 , a major protein involved in ES cells self-renewal, which leads specifically to inhibition of ES cells differentiation