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FGF3 — KL
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
FGF3
→
KL
(reaction)
Carpenter et al., Exp Cell Res 1999, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Agazie et al., Oncogene 2003, Ahmed et al., Biochem J 2008, Schüller et al., Biochem J 2008, Klint et al., J Biol Chem 1995, Wang et al., Mol Cell Biol 1994, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Kurosu et al., J Biol Chem 2006
:
To test the possibility that Klotho and FGF23 may function in a common signal transduction pathway ( s ), we investigated whether
Klotho is
involved in
FGF signaling
Fukumoto et al., Bone 2007
(Hypophosphatemia) :
Furthermore,
FGF23 requires
Klotho for its signaling in addition to a canonical FGF receptor
Mazzaferro et al., G Ital Nefrol 2009
(Chronic Disease...) :
Interestingly,
FGF23 has very low affinity for its receptor and
requires the activity of
Klotho , an anti aging gene, to become active
Château et al., Aging 2010
:
Besides revealing a new post-developmental role for EGL-17, our data suggest that the KL1 form of
Klotho is
involved in FGF23 independent
FGF signalling
Li et al., Mol Cell Endocrinol 2012
:
In hepatocyte,
FGF-21 up-regulation
reduced HMGR and PEPCK mRNA expression and increased
ß-klotho , FGFR4 and LDLr expression ( p < 0.05 ), whereas down-regulation had the opposite effects
Razzaque et al., Adv Exp Med Biol 2012
(Kidney Diseases) :
Vitamin D can
induce the expression of both FGF23 and
klotho while,
FGF23 can suppress renal expression of 1a ( OH ) ase to reduce 1,25 ( OH ) ( 2 ) D activity
Bhattacharyya et al., Trends Endocrinol Metab 2012
(Iron Metabolism Disorders...) :
In physiologic states,
FGF23 signaling is
mediated by an FGF receptor and the coreceptor,
Klotho