Gene interactions and pathways from curated databases and text-mining

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PRNP — SP1

Text-mined interactions from Literome

Sakudo et al., Curr Protein Pept Sci 2010 (Prion Diseases) : Our results have shown that the specific protein 1 (Sp1) plays important role in the activity of PrP gene promoter, which is influenced by polymorphisms in the Sp1 binding sites
Jeong et al., Biochem Biophys Res Commun 2012 (Prion Diseases) : Transcriptional regulation of specific protein 1 (SP1) by hypoxia-inducible factor 1 alpha ( HIF-1a ) leads to PRNP expression and neuroprotection from toxic prion peptide