Gene interactions and pathways from curated databases and text-mining

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IL8 — SIGLEC7

Text-mined interactions from Literome

Frishman et al., J Infect Dis 2000 : Spontaneous IL-8 production was increased by p75-Fc or native p75 but not by p55-PEG or native p55
Mercado et al., PloS one 2012 (Asthma) : Corticosteroid sensitivity was determined by measuring dexamethasone inhibition of CD3/28 and TNF-a induced IL-8 production in PBMCs by using ELISA
Varchetta et al., PloS one 2012 (MAP Kinase Signaling System) : Here, we demonstrate that cross linking of Siglec-7 by a specific monoclonal antibody ( mAb ) induces a remarkably high production of IL-6, IL-1a, CCL4/MIP-1ß, IL-8 and TNF-a