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CD86 — IFNG
Text-mined interactions from Literome
Liu et al., Scand J Immunol 1999
(Lupus Erythematosus, Systemic) :
Interferon-gamma (IFN-gamma) increased both CD80 and
CD86 expression on monocytes from both SLE patients and normal groups, albeit less significantly in the former than in the latter, i.e. CD80 : 142.84+/-65.99 % versus 226.08+/-78.90 %, P < 0.05 ; and CD86 : 72.55+/-74.23 % versus 153.99+/-94.14 %, P < 0.05, when expressed as percentage modulation ... We concluded that CD80 and CD86 were differentially expressed and modulated on monocytes and the defective
IFN-gamma induced
up-regulation of CD80 and
CD86 expression on SLE monocytes might be a factor in the pathogenesis of SLE
Frucht et al., Clin Immunol 1999
(Mycobacterium avium-intracellulare Infection) :
CD86 blockade
caused a greater than 50 % reduction in both normal and familial patient
interferon-gamma production, implying that a majority of residual familial patient costimulation required this pathway
Subauste et al., J Immunol 2000
:
IL-12 independent
IFN-gamma production
required CD80/CD86-CD28 interaction and, to a lesser extent, CD40-CD40L signaling
Jeannin et al., Immunity 2000
:
CD86deltaTM also
induces IFNgamma production by virus-specific CD8+ memory human T cells stimulated with the Flu M1 peptide
Magistrelli et al., Biochem Biophys Res Commun 2001
:
The activation of monocytes by
IFNgamma (i) induces the preferential expression of the transcript encoding for the membrane form and ( ii )
increases the expression of
CD86 and of the accessory molecules CD40, CD49d and CD54
Matsumura et al., Ann Rheum Dis 2001
(Lymphadenitis...) :
Interferon gamma (IFNgamma) consistently up
regulated levels of CD80 and
CD86 ...
IFNgamma consistently up
regulated CD86 expression ... Salivary ductal cells in patients with SS can express CD80 and
CD86 costimulatory molecules in
response to
IFNgamma
Blazevic et al., J Clin Immunol 2001
:
Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and
anti-CD86 inhibited influenza-specific T cell proliferation, interleukin (IL)-2 and
interferon (IFN)-gamma production, and generation of influenza-specific CD8+ CTL
Ponte-Sucre et al., Immunopharmacol Immunotoxicol 2001
(Leishmaniasis) :
We provide evidence that in BALB/c murine macrophages, GLIB induced a decrease in the
interferon-gamma stimulated expression of major histocompatibility complex class II molecules and the co-stimulatory molecule
CD86 ( B7-2 )
Tsunawaki et al., J Rheumatol 2002
(Sjogren's Syndrome) :
Interferon-gamma (IFN-gamma) induced the cultured salivary gland epithelial cells to express HLA class I antigens, HLA-DR antigens, CD80, and ICAM-1, while tumor necrosis factor-alpha (TNF-alpha) induced the expression of HLA class I antigens, CD80,
CD86 , and VCAM
Sindhi et al., J Immunol Methods 2003
:
PD analyses suggested that in NHS samples containing CsA+SRL ( n=5 ), ( 1 ) PMA-Ionomycin stimulated T-cell expression of intracellular IL-2, TNF-alpha, and
IFN-gamma was inhibited by CsA, and minimally by SRL, and ( 2 ) the two agents
inhibited pokeweed mitogen ( PWM ) -stimulated B-cell expression of CD54 and CD95, but not
CD86 ( ICAM-1, Fas antigen, and B7.2 ), synergistically
Rutkowski et al., Arch Immunol Ther Exp (Warsz) 2003
(Asthma) :
CD80 and
CD86 expression on LPS stimulated monocytes and the
effect of CD80 and CD86 blockade on IL-4 and
IFN-gamma production in nonatopic bronchial asthma
Shi et al., Zhonghua Yi Xue Za Zhi 2003
:
When instilled intratracheally in ovalbumin sensitized recipient mice, these antigen loaded eosinophils migrated into draining paratracheal lymph nodes primed Th2 cells in vivo for IL-4, IL-5 and IL-13, but not
IFN-gamma , production during the in vitro culture that was also CD80- and
CD86 dependent
Shi et al., Allergy 2004
:
When instilled intratracheally in sensitized recipient mice, airway eosinophils migrated into draining paratracheal lymph nodes primed Th2 cells in vivo for IL-4, IL-5, and IL-13, but not
IFN-gamma , production during the in vitro culture that was also CD80- and
CD86 dependent
Gutzmer et al., Immunology 2004
:
After up-regulation of the C3aR by IFN-alpha+
IFN-gamma , C3a significantly
up-regulated the surface expression of CD54, CD83 and
CD86 , but not of CD40, CD80 or human leucocyte antigen ( HLA ) -DR. C3a had no effect on the production of interleukin (IL)-10 or IL-12p70, or on the capacity of MoDC to stimulate autologous T-cell proliferation
Xie et al., Chin Med J (Engl) 2005
:
When instilled intratracheally in sensitized recipient mice, airway EOSs primed lung Th2 cells in vivo for interleukin-4, interleukin-5 and interleukin-13, but not
interferon-gamma , production during the in vitro culture that was also CD80- and
CD86 dependent
Neves et al., Cancer Immunol Immunother 2005
(Carcinoma, Renal Cell...) :
Dendritic cells derived from metastatic cancer patients vaccinated with allogeneic dendritic cell-autologous tumor cell hybrids express more
CD86 and
induce higher levels of
interferon-gamma in mixed lymphocyte reactions
Nakahara et al., Clin Exp Immunol 2005
(Neoplasms) :
Our results show that
IFN-gamma , but not IL-1beta,
augmented the surface expression of CD80, CD83 and
CD86 molecules without inducing IL-12 production from DCs
Makino et al., Cell Immunol 2005
(Leprosy) :
The DC-mediated
IFN-gamma production was
dependent on the expression of MHC,
CD86 , and MMP-II antigens
Li et al., J Immunol 2006
(Glomerulonephritis) :
Following i.p. immunization,
CD86 , but not CD80,
promotes early Ag-specific TCR-transgenic DO11.10 CD4+ cell proliferation and
IFN-gamma production, suggesting that CD100 expression enables full expression of CD86 and consequent CD4+ cell activation
Yadav et al., J Leukoc Biol 2006
:
IFN-gamma production was also shown to be
important for enhanced T-bet gene expression but not important for up-regulation of
CD86
Muralimohan et al., Cell Immunol 2006
:
Nonetheless, pDCs strictly
required IFNgamma for upregulation of
CD86 and CD40, but cDCs did not depend upon IFNgamma for activation
Steers et al., Vaccine 2008
:
L ( LA ) enhanced the surface expression of MHC class I, class II, CD80, and
CD86 molecules,
induced the secretion of
IFN-gamma , IL-12p40, TNF-alpha and IL-10, and caused a shift in the proteasome profile from constitutive to immunoproteasomes as observed by the induction of beta2i, beta5i, PA28alpha, and PA28beta subunits
Nguyen et al., Cytotherapy 2008
:
At a contaminating concentration of 5 Plt/MO, matured DC showed the highest expression of HLA-DR, CD80 and
CD86 ,
inducing a strong T-cell proliferation with high production of IL-4 and
interferon-gamma
Izawa et al., Biochem Biophys Res Commun 2010
:
Moreover, P-gp blockade, compared to controls, attenuated intragraft expression of CD3 and CD80, but not
CD86 , and
inhibited IFN-gamma and IL-4 production ( P < 0.05 )
Petro et al., Immunol Invest 1995
:
Production of
IFN-gamma was significantly
blocked by either anti-CD80 and
anti-CD86
Ozawa et al., Eur J Immunol 1996
:
Based on the recently reported
effect of
interferon (IFN)-gamma and interleukin (IL-)-10 on the expression of CD80 and
CD86 by LC, we examined the effects of these cytokines on the expression of CD54 ( intercellular adhesion molecule-1 ) and CD40 in addition to CD80 and CD86 on LC, and correlated the expression of each co-stimulatory molecule with antigen presentation for a Th1 clone by cultured LC (cLC) treated with these cytokines
Yokozeki et al., Br J Dermatol 1997
:
Interferon-gamma differentially
regulates CD80 ( B7-1 ) and
CD86 ( B7-2/B70 ) expression on human Langerhans cells ... These data indicate that the CD80 and
CD86 expression of human LCs may be differently
regulated by
IFN-gamma
Subauste et al., J Immunol 1998
:
Moreover, proliferation and
IFN-gamma production by CD4+ CD45RA+ T cells from unexposed individuals were
dependent on both CD80 and
CD86