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MECP2 — MYLIP
Text-mined interactions from Literome
Klein et al., Nat Neurosci 2007
:
Block of miR132 mediated repression increased MeCP2 and brain derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of
MeCP2 reduced BDNF and
miR132 levels in vivo
Nomura et al., Hum Mol Genet 2008
(Fragile X Syndrome...) :
MeCP2 dependent repression of an imprinted
miR-184 released by depolarization ... The restricted release of
MeCP2 from the paternal allele
results in paternal allele-specific expression of
miR-184
Wada et al., Int J Cancer 2010
(Intestinal Neoplasms...) :
miR-212 is downregulated and
suppresses methyl-CpG binding protein
MeCP2 in human gastric cancer ... Ectopic expression of
miR-212 repressed expression of the
MeCP2 protein but not the MECP2 mRNA level
Szulwach et al., J Cell Biol 2010
:
MeCP2 mediated epigenetic
regulation of one such miRNA,
miR-137 , involves coregulation by Sox2, a core transcription factor in stem cells
Lu et al., Exp Cell Res 2013
(Down Syndrome) :
The expression levels of
miR-155 and miR-802 in T21 AF-iPS-NPCs were highly elevated in the
presence of low expression of
MeCP2
Ji et al., Carcinogenesis 2013
(Cell Transformation, Neoplastic) :
Moreover, inhibition of
miR-152 expression in 16HBE cells could increase DNMT1 expression and
result in an increase in DNA methylation, DNMT1 and
MeCP2 binding to miR-152 promoter, indicating an interaction between miR-152 and DNMT1 is regulated by a double negative circuit
Han et al., Genes Dev 2013
:
Human-specific
regulation of
MeCP2 levels in fetal brains by microRNA
miR-483-5p ... Here, we show that
miR-483-5p , an intragenic microRNA of the imprinted IGF2,
regulates MeCP2 levels through a human-specific binding site in the MECP2 long 3 ' UTR ... These data provide insight into the
role of
miR-483-5p in regulating the levels of
MeCP2 and interacting proteins during human fetal development