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IFNG — PSMB9

Text-mined interactions from Literome

Lee et al., Cancer Res 2000 (Neoplasm Metastasis...) : IFN-gamma induced surface class I MHC expression, as well as gene expression of TAP-1, TAP-2, LMP-2 , and LMP-7 in the metastatic cells, yet the cells remained resistant to cell lysis induced by CTLs. Interestingly, although in comparison to the primary cells the metastatic cells were resistant to cytolysis, both cell types were susceptible to DNA fragmentation induced by CTLs. Cell fusion between primary and metastatic cancer cells resulted in hybrids that also resisted the cytolytic activity of CTLs
van Hall T et al., J Exp Med 2000 : Interferon (IFN)-gamma induces expression of three catalytically active proteasome subunits ( LMP2 , LMP7, and MECL-1 ) and the proteasome associated activator PA28
Tahara et al., Int J Oncol 2000 : IFN-gamma treatment induced the TAP-1 and LMP-2 genes, continuously up-regulated the HLA class I expression and increased cytolysis
Dovhey et al., Cancer Res 2000 (Carcinoma, Renal Cell...) : Loss of interferon-gamma inducibility of TAP1 and LMP2 in a renal cell carcinoma cell line ... The effects of IFN-gamma on TAP1 and LMP2 expression revealed a loss of up-regulation in Caki-2 cells, but not in Caki-1 cells
Brucet et al., Genes Immun 2004 : Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1 ... In macrophages from STAT1 knockout mice, IFN-gamma did not induce the expression of Tap-1 or Lmp-2 ... By making deletions of the promoter, we found that only the proximal GAS and IRF-1 boxes are required for IFN-gamma induction of Tap-1 and Lmp-2 ... These results indicate that both STAT1 and IRF-1 are required for the IFN-gamma induction of Tap-1 and Lmp-2 genes
Hayashi et al., Oncogene 2006 (Leiomyoma...) : The mutation in the ATP binding region of JAK1, identified in human uterine leiomyosarcomas, results in defective interferon-gamma inducibility of TAP1 and LMP2 ... The TAP1 and LMP2 genes are transcribed from a shared bidirectional promoter containing an interferon (IFN)-gamma-response factor element ; thus, the IFN-gamma-signal strongly induces both TAP1 and LMP2 expression
François et al., Blood 2009 : However, although the transcription of the transporter associated with antigen processing-1 molecules and the immunoproteasome subunit LMP2 induced by IFN-gamma was inhibited by transforming growth factor-beta, the overall cross-presentation capacity of MSCs remained unchanged after transforming growth factor-beta treatment
Hayashi et al., Gene regulation and systems biology 2008 : The LMP2 gene is transcribed from a promoter containing an interferon (IFN)-gamma-response factor element ; thus, the IFN-gamma-signal strongly induces LMP2 expression
Bardag-Gorce et al., Exp Mol Pathol 2010 (Disease Models, Animal...) : SAMe prevented the increase in the TNFalpha and IFNgamma receptors, supporting the idea that TNFalpha and IFNgamma were responsible for the up regulation of LMP2 , LPM7, and FAT10
Sibille et al., Curr Biol 1995 (Lymphoma, T-Cell) : Expression of IFN-gamma in transfected SP3 cells simultaneously restores LMP2 expression and antigen presentation to CTL
Früh et al., EMBO J 1994 : In the experiments reported in this communication we studied the subunit changes occurring in cell lines where the expression of LMP2 or LMP7 can be regulated individually either by IFN-gamma induction or by applying a new system to control the expression of transfected LMPs
Aki et al., J Biochem 1994 (Colonic Neoplasms...) : IFN-gamma greatly increased the levels of the mRNAs encoding LMP2 and LMP7, putative immuno-proteasome subunits encoded by genes within the class II MHC region, and these two subunits synthesized were assembled completely into the proteasomal multi-subunit complex in various types of human cells
Brown et al., J Immunol 1993 : The expression of LMP2+ and LMP2- proteasomes is variable among cell lines of different tissue types, and their relative abundance and subunit composition are regulated by IFN-gamma
Gaczynska et al., J Biol Chem 1996 : Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma induced subunits LMP2 and LMP7
Fujimaki et al., Neuroreport 1996 : Expression of Tap-1 and Lmp-2 genes, which are involved in antigen processing and presentation, was also induced by IFN-gamma treatment
Chatterjee-Kishore et al., J Biol Chem 1998 (Melanoma) : However, LMP2 expression requires induction by interferon-gamma in most cells
Seliger et al., Clin Cancer Res 1997 (Carcinoma, Renal Cell...) : Analysis of the dual TAP-1/LMP-2 promoter activity revealed that TAP-1 and LMP-2 expression are controlled by IFN-gamma at the transcriptional level ... Thus, the IFN-gamma mediated coordinated transcriptional up-regulation of TAP-1 and LMP-2 expression occurs through the use of a common regulatory element, which might result in enhanced recognition of renal cell carcinoma cells by the immune system