Yen et al., Mol Pharmacol 2005
:
The use of pharmacological inhibitors or genetic inhibition revealed that both the phosphatidylinositol 3-kinase (PI3K)/Akt and p38 signaling pathways were potentially required for diosgenin induced HIF-1 activation and subsequent VEGF-A up-regulation
Nys et al., J Invest Dermatol 2010
(Carcinoma, Squamous Cell...) :
Furthermore, p38 ( MAPK ) was required for the induction and activation of hypoxia-inducible factor 1 (HIF-1) in response to UVB, and HIF-1 knockdown reduced Noxa expression and apoptosis