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IFNG — TLR2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TLR2 → IFNG (increases)
  Evidence: Type-1 cytokines including IL-1?, TNF-? and IFN-? induced a strong up-regulation of TLR2 mRNA (Fig. 8) and protein expression that was most pronounced by the co-stimulation with TNF-? and IFN-? (Fig. 5).

Text-mined interactions from Literome

Faure et al., J Immunol 2001 (Inflammation...) : Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells : role of NF-kappa B activation ... Here we show that LPS, TNF-alpha, or IFN-gamma induce TLR2 expression in both human dermal microvessel EC and HUVEC
Mita et al., Immunol Lett 2001 : IFN-gamma up-regulated both TLR2 and TLR4, but enhanced the surface expression, on human peripheral blood monocytes of TLR4 more than that of TLR2
Tamai et al., Infect Immun 2002 : To elucidate the mechanism of the priming effects of IFN-gamma for the LPS response by HGF, we examined whether IFN-gamma regulated expression of CD14, Toll-like receptor 2 (TLR2) , TLR4, MD-2, and MyD88, all of which are molecules suggested to be associated with LPS signaling
Seki et al., J Immunol 2002 (Inflammation...) : As TLR2 KO, but not TLR4 KO, mice showed partial impairment in their capacity to produce IL-12, IFN-gamma, and TNF-alpha, TLR2 activation partly contributed to the induction of IL-12 mediated IFN-gamma production
Pivarcsi et al., Int Immunol 2003 : LPS + IFN-gamma increased the expression of TLR2 and TLR4 50- and 5-fold respectively
Alvarez et al., J Immunol 2003 : Mycobacterium avium inhibition of IFN-gamma signaling in mouse macrophages : Toll-like receptor 2 stimulation increases expression of dominant negative STAT1 beta by mRNA stabilization
Pai et al., Infect Immun 2004 : Microarray gene expression studies were then used to determine whether prolonged TLR signaling by M. tuberculosis broadly inhibits IFN-gamma regulation of macrophage gene expression
Cook et al., Ann Allergy Asthma Immunol 2005 (Conjunctivitis...) : Expression of TLR-2 was up-regulated on conjunctival epithelial cells by IFN-gamma and Staphylococcus aureus-CWE
Mueller et al., J Immunol 2006 : The down-regulatory effect of Th2 cytokines on TLR expression and function in IECs also counteracted enhanced TLR signaling induced by stimulation with the hallmark Th1 cytokine IFN-gamma
Eriksson et al., J Immunol 2006 : However, purified uNK cells did not respond directly to TLR agonists, but IFN-gamma was produced by uNK cells in response to TLR stimulation when cocultured with APCs
Taylor et al., J Allergy Clin Immunol 2006 : Although the whole staphylococcal bacteria increased IFN-gamma responses, the purified TLR2 ligands lipoteichoic acid and Pam3CSK4 inhibited HDM-specific IFN-gamma synthesis
Velayudham et al., J Hepatol 2006 (Granuloma...) : IFNgamma induction by P. acnes, TLR2 and TLR9 ligands required MyD88
Ramakers et al., Cytokine 2006 : In more detail, CPA potentiated TLR5 mediated IL-6 production, TLR3 mediated IFN-gamma production and TLR3 mediated Il-1beta production compared to TLR4 mediated stimulation
Sawaki et al., Int Immunol 2007 : The tlr2 ( -/- ) or tlr7 ( -/- ) NK cells could not produce IFN-gamma in response to IL-12 plus TLR2 or TLR7 ligands, respectively, indicating requirement of the corresponding TLRs
Hu et al., J Leukoc Biol 2007 : IFN-gamma suppresses TLR2 and TLR4 induction/activation of AP-1 by overlapping mechanisms that include regulation of MAPKs, GSK3 dependent suppression of DNA binding, and decreased Fos and Jun protein expression and stability
Imanishi et al., J Immunol 2007 : In mouse Th1 cells the stimulation by TLR2 but not by other TLRs directly induced IFN-gamma production, cell proliferation, and cell survival without TCR stimulation, and these effects were greatly enhanced by IL-2 or IL-12 through the enhanced activation of MAPKs
Tang et al., Proc Natl Acad Sci U S A 2007 (Brain Ischemia...) : We now report that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-gamma stimulation and energy deprivation
Schierloh et al., Infect Immun 2007 (Pleural Effusion...) : The mannose receptor seems to mediate the inhibitory effect of mannosylated lipoarabinomannan, and Toll-like receptor 2 and 4 agonists activate NK cells but do not induce IFN-gamma like M. tuberculosis does
Daehnel et al., Parasite Immunol 2007 (Disease Models, Animal...) : Taken together, these findings demonstrate an essential role for TLR2 in filaria induced dendritic cell activation, IFN-gamma production and neutrophil migration to the cornea, but does not affect filaria induced Th2 associated responses
Hong et al., Infect Immun 2007 : These findings indicate that TLR2 controls hepatic lymphocyte IFN-gamma responses to F. tularensis by regulating DC IL-12 production
Girart et al., J Immunol 2007 (Melanoma) : Engagement of TLR3, TLR7 , and NKG2D regulate IFN-gamma secretion but not NKG2D mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12
Barr et al., Eur J Immunol 2007 : In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll-like receptors ( TLR ) in the control of secretion of IL-6, IL-10, IL-12 and IFN-gamma by B cells ... Thus, in response to combined TLR stimulation, or via phorbol esters, IFN-gamma was secreted
Allam et al., J Allergy Clin Immunol 2008 : Moreover, TLR4-ligation on oLCs induced IL-10, TGF-beta1, Forkhead box protein 3, IFN-gamma , and IL-2 production in T cells
O'Mahony et al., International journal of medical sciences 2008 : Of the cytokines examined, IFN-gamma and GM-CSF caused the greatest effects on TLR expression ... IFN- gamma up-regulated TLR2 and TLR4 in neutrophils and monocytes
Prescott et al., J Allergy Clin Immunol 2008 (Hypersensitivity...) : Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3 , and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Archer et al., Cell Microbiol 2009 : Thus, MyD88 dependent innate immune responses induced by L. pneumophila involve both TLR dependent responses and IL-18R dependent production of IFN-gamma by natural killer cells, and these MyD88 dependent pathways can function independently to provide host protection against an intracellular pathogen
Yarovinsky et al., J Immunol 2008 (Acute Disease...) : We further show that this immunopathology is the result of non-TLR dependent activation of IFN-gamma secretion by NK cells in response to the infection
Lotter et al., PLoS Pathog 2009 (Disease Models, Animal...) : IFN-gamma production by NKT cells requires the presence of CD1d and simultaneously TLR receptor signalling through MyD88 and secretion of IL-12
Chassin et al., J Immunol 2009 (Genetic Predisposition to Disease...) : We also found a protective tissue compartmentalized TLR2/TLR4 mediated production of IFN-gamma by B and T lymphocytes, in the liver and kidney, respectively
Devilder et al., J Immunol 2009 : Moreover TLR induced Vgamma9Vdelta2 IFN-gamma noncytolytic response led to efficient DC polarization into IL-12p70 producing cells
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma , interleukin-4, or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Cui et al., Biology direct 2009 : Third, the expressions of both Toll-like receptor (TLR)2 and TLR4 on surface of LA-activated gammadelta T cells were upregulated, whereas only anti-TLR4 antibody could partially block their response to LA ; Finally LA-loaded moDCs induce gammadelta T cells to produce Th1 cytokines, such as IFN-gamma
van Hoffen et al., Int Arch Allergy Immunol 2010 : Apically added LGG, TLR2 and NOD2 ligands, but not Bb, enhanced IFN-gamma , IL-12 and/or TNF-alpha secretion
Fang et al., FEMS Immunol Med Microbiol 2010 (West Nile Fever) : Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or toll-like receptor ( TLR ) agonist treatment of gammadelta T cells induced the production of IFN-gamma , tumor necrosis factor-alpha and IL-6, which are known to promote DC maturation
Brisbin et al., Benef Microbes 2012 : The results demonstrated that chicken CD4+ and CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially induces the expression of interleukin 10, interferon-gamma and transforming growth factor beta