Zhang et al., J Neurochem 2006
(Neuroblastoma) :
In mitotic neural cells DN-TRF2 induced activation of both p53 and p21 and senescence ( as indicated by an up-regulation of beta-galactosidase ) ... In contrast, in neurons DN-TRF2 increased p21, but neither p53 nor beta-galactosidase was induced Stagno D'Alcontres et al., J Cell Biol 2007
:
Lack of TRF2 in ALT cells causes PML dependent p53 activation and loss of telomeric DNA
Spallarossa et al., Am J Physiol Heart Circ Physiol 2009
:
p38 modulates TRF2 expression, whereas JNK and cytoplasmic p53 regulate TRF1 ... In conclusion, various doses of doxorubicin induce differential regulation of TRF1 and TRF2 through p53 and MAPK, which is responsible for inducing either early apoptosis or senescence and late death due to mitotic catastrophe
Fujita et al., Nat Cell Biol 2010
:
Experimental manipulation of p53 expression demonstrated that p53 induces Siah1 and represses TRF2 protein levels