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HSP90B1 — TLR2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TLR2 → HSP90B1 (increases, HSP90B1 Activity)
  Evidence: endogenous ligands are being reported as candidate stimulators of TLRs, in particular of TLR2 and TLR4. These include heat shock proteins (HSP60, HSP70, endoplasmin, HSPB8 and ?-crystallin A chain)7–13, high mobility group box 1 (HMGB1)14,15, uric acid crystals16,17, surfactant protein A18, and various products of the extracellular matrix such as fibronectin19, heparan sulphate20, biglycan21, fibrinogen22, oligosaccharides of hyaluronan23 and hyaluronan breakdown fragments24–26.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TLR2 — HSP90B1 (in vivo) Vabulas et al., J Biol Chem 2002*
• IRef Ophid Interaction: TLR2 — HSP90B1 (aggregation, confirmational text mining) Vabulas et al., J Biol Chem 2002*
• IRef Ophid Interaction: TLR2 — HSP90B1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005