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CCND3 — IL2

Text-mined interactions from Literome

Flores et al., J Immunol 1999 : When the IL-2 regulated cell cycle control checkpoints are examined in detail, we demonstrate that inhibition of diacylglycerol kinase activation prevents IL-2 induction of cyclin D3 without affecting p27 down-regulation
Malek et al., J Immunol 2001 : IL-2 is required for these functions in part by regulation of cyclin D3 and granzyme B
Engedal et al., J Immunol 2006 : Furthermore, the stimulatory effect of RA on cyclin D3 expression as well as on cell proliferation was completely abolished in the presence of the JAK inhibitor AG-490 or blocking IL-2R alpha mAbs, and RA also enhanced cyclin D3 expression and T cell proliferation in the presence of IL-2 alone
Charvet et al., J Immunol 2006 : Importantly, IL-2 induced p27 kip1 down-regulation and cyclin D3 up-regulation and FOXO1 phosphorylation were similar in Vav1 ( -/- ) and wild-type T lymphoblasts, indicating that defective FOXO1 phosphorylation and p27 kip1 and cyclin D3 expression do not result from deficient IL-2 signaling in the absence of Vav1
Wagner et al., J Immunol 1998 : A pivotal role of cyclin D3 and cyclin dependent kinase inhibitor p27 in the regulation of IL-2- , IL-4-, or IL-10 mediated human B cell proliferation ... Taken together, our findings suggest that cyclin D3 , cdk6, and p27 play key roles in IL-2- , IL-4-, and IL-10 mediated human B cell proliferation