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MAPK14 — RB1

Pathways - manually collected, often from reviews:

• BioCarta human cytomegalovirus and map kinase pathways: p38 (MAPK14) → RB (RB1) (modification, activates)
• NCI Pathway Database Regulation of retinoblastoma protein: p38alpha-beta-active (MAPK14/MAPK11) → RB1 (RB1) (modification, activates) Li et al., Arch Biochem Biophys 2001
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK14 — RB1 (direct interaction, enzymatic study) Delston et al., Oncogene 2011*
• IRef Biogrid Interaction: MAPK14 — RB1 (physical association, affinity chromatography technology) Li et al., Arch Biochem Biophys 2001
• IRef Intact Interaction: MAPK14 — RB1 (phosphorylation reaction, protein kinase assay) Inoue et al., EMBO J 2007*
• IRef Intact Interaction: MAPK14 — RB1 (phosphorylation reaction, protein kinase assay) Delston et al., Oncogene 2011*

Text-mined interactions from Literome

von Willebrand et al., Cancer Res 2003 (MAP Kinase Signaling System...) : Thus, inhibition of melanoma cell proliferation by AG1024 is mediated by inhibition of mitogen activated protein kinase/extracellular signal regulated kinase 2 signaling and activation of pRb by a mechanism involving protein degradation
Song et al., Yao Xue Xue Bao 2008 : [ JNK/p38 MAPK involves in ginsenoside Rb1 attenuating beta-amyloid peptide ( 25-35 ) -induced tau protein hyperphosphorylation in embryo rat cortical neurons ]
Yeste-Velasco et al., Neurochem Int 2009 (Retinal Neoplasms...) : In conclusion, these results suggest that p38MAPK converged with the cell cycle in S/K deprivation induced apoptosis through pRb phosphorylation