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PAK1 — PLCG1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
PAK1
→
PLCG1
(reaction)
Chong et al., J Biol Chem 2001, Parrini et al., Mol Cell 2002, Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Lu et al., Oncogene 1999
-
Reactome Reaction:
PAK1
→
PLCG1
(indirect_complex)
Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Lu et al., Oncogene 1999
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Shin et al., Exp Mol Med 2002
:
Phospholipase C-gamma1 ( PLC-gamma1 ) can
mediate the
PAK translocation in response to growth factors, since PLC-gamma1 binds to both tyrosine phosphorylated receptor tyrosine kinases and PAK through its SH2 and SH3 domain, respectively ... In the present study, we examined a potential
role for
PLC-gamma1 in the basic fibroblast growth factor (bFGF) induced
PAK translocation using stable PC12 cell lines that overexpress in a tetracycline-inducible manner either the wild-type FGFR-1 or the Y766F FGFR-1 mutant
Rouquette-Jazdanian et al., Mol Cell 2012
(MAP Kinase Signaling System) :
The
PLC-?1 ( SH3 ) -Pak1 interaction
activates Pak1 independently of the small GTPases Rac1/Cdc42, previously described as being the only activators of Pak1 in T cells