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CSE — DISC1

Text-mined interactions from Literome

Kim et al., Autophagy 2008 (Necrosis...) : Reduction of Beclin 1 levels with beclin 1 siRNA inhibited DISC formation and caspase-3/8 activation in response to CSE ... Conversely, transfection of Beas-2b with ho-1 siRNA augmented CSE induced DISC formation and increased intracellular reactive oxygen species formation ... Consistently, expression of IkappaB, the inhibitor of NFkappaB, increased CSE induced DISC formation ... In fibroblasts from beclin 1 heterozygous knockout mice, p65 phosphorylation was dramatically upregulated, while CSE induced DISC formation was inhibited, consistent with an anti-apoptotic role for NFkappaB and a pro-apoptotic role for Beclin 1
Park et al., J Toxicol Sci 2010 : We demonstrated cigarette smoke extract (CSE) induced DISC formation in human lung fibroblasts ( MRC-5 ) ... We demonstrated that CSE induces DISC formation in MRC-5 using IP for Fas and IB for caspase 8