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BCR — NOD2

Text-mined interactions from Literome

Hussain et al., J Immunol 2005 (Diabetes Mellitus, Type 1...) : B7 blockade of BCR stimulated NOD B cells by anti-B7-1 and anti-B7-2 mAbs during coadoptive transfer with diabetogenic T cells into NOD.scid mice protected these recipients from T1D
Hussain et al., J Immunol 2007 (Diabetes Mellitus, Type 1) : In this study, we demonstrate that i.v. transfusion of BCR stimulated NOD spleen B cells into NOD mice starting at 5-6 wk of age both delays onset and reduces the incidence of T1D, whereas treatment initiated at 9 wk of age only delays onset of T1D ... Consistent with this result, severe insulitis was observed in the islets of NOD recipients of transfused NOD.IL-10 ( -/- ) BCR stimulated B cells but not in the islets of NOD recipients of transfused BCR stimulated NOD B cells ... The therapeutic effect of transfused activated NOD B cells correlates closely with the observed decreased islet inflammation, reduced IFN-gamma production and increased production of IL-4 and IL-10 by splenocytes and CD4 ( + ) T cells from NOD recipients of BCR stimulated NOD B cells relative to splenocytes and CD4 ( + ) T cells from PBS treated control NOD mice