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CRH — LEP

Text-mined interactions from Literome

Brunetti et al., Eur J Pharmacol 1999 : We have investigated the role of NO, prostaglandin E2 and prostaglandin F2alpha as mediators of the hypothalamic effects of leptin and their possible involvement in leptin stimulated CRH secretion ... Using primary cultures of neonatal ( 5- to 6-day-old ) rat hypothalamic cells, we confirmed that leptin ( 0.1-10 nM ) stimulates CRH secretion ... Cyclooxygenase inhibition by indomethacin ( 10 microM ) did not modify leptin induced CRH secretion, while leptin stimulated prostaglandin E2, and prostaglandin F2alpha secretion ... In conclusion, leptin induced hypothalamic CRH secretion is not modulated by NO-synthase- or cyclooxygenase mediated mechanisms ; leptin does not stimulate NO production, but it stimulates prostaglandin E2 and F2alpha production, which could add to the growing list of mediators of leptin signaling in the hypothalamus
Morimoto et al., Neuroendocrinology 2000 : The leptin induced CRH mRNA expression in the PVN and POMC mRNA expression in the pituitary were also reduced by the pretreatment with OPC-21268 and dP [ Tyr ( Me)(2 ) ] AVP
Jang et al., J Nutr 2000 : Leptin rapidly inhibits hypothalamic neuropeptide Y secretion and stimulates corticotropin releasing hormone secretion in adrenalectomized mice ... No rapid-onset effects of leptin on hypothalamic NPY or CRH concentrations were observed in intact mice
Shimizu et al., Nihon rinsho. Japanese journal of clinical medicine 2001 : Melanin concentrating hormone, orexin, and corticotropin releasing hormone may be directly regulated by leptin
Okamoto et al., Neurosci Lett 2001 : Anorectic effect of leptin is mediated by hypothalamic corticotropin releasing hormone , but not by urocortin, in rats ... These results suggest that the anorectic effect of leptin is mediated by CRH , but not by urocortin, in the hypothalamus
Ghizzoni et al., J Clin Endocrinol Metab 2001 : The negative correlation, with cortisol leading leptin by 4 and 3 h for boys and girls, respectively, might reflect the stimulatory effect of CRH on the sympathetic system, which inhibits leptin secretion ; the positive correlation, with leptin leading cortisol by 6 and 5 h for boys and girls, respectively, might reflect a direct effect of leptin on CRH secretion in the hypophyseal portal system
Proulx et al., Endocrinology 2002 (Weight Gain) : Chronic leptin increased corticotropin releasing factor receptor-2 mRNA levels in the ventromedial hypothalamus
Toftegaard et al., Regul Pept 2003 : Finally, alpha-FMH suppressed basal and leptin induced CRH expression while stimulating NPY expression in fasted rats
Hashimoto et al., Peptides 2004 : Peripheral injection of leptin increased VMH CRF2 receptor mRNA, as can induce reductions of food intake and body weight, indicating that circulating leptin is involved in the regulation of VMH CRF2 receptor mRNA expression
Jethwa et al., Endocrinology 2006 : In this study, leptin ( 1 nm ) significantly increased the release of CRH from ex vivo hypothalamic explants by 207 +/- 8.4 % ( P < 0.05 vs. basal ), an effect blocked by the administration of anti-NMU IgG
Huang et al., J Endocrinol 2006 (Anorexia...) : Regulation of corticotropin releasing factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running induced stress
Fahlbusch et al., Reproductive biology and endocrinology : RB&E 2012 (Fetal Growth Retardation) : We hypothesized that CRH might attenuate syncytialisation, induce leptin , and reduce 11beta-HSD2 expression in primary villous trophoblasts, which are known features of IUGR ... The induction of leptin and 11beta-HSD2 in the syncytiotrophoblast by CRH might promote fetal nutrient supply and placental corticosteroid metabolism in the phase before labour induction
Costa et al., Neuroreport 1997 (Obesity) : We tested in vitro the effect of murine leptin on CRH secretion in the dose range of 0.1 pM-100 nM ... The active leptin , but not the heat inactivated peptide, caused a dose dependent stimulation of CRH release in vitro ( p < 0.05- < 0.0001 vs control ), with a plateau effect at a dose of 10 nM ... The addition of either prazosin or propranolol was without effect on leptin dependent CRH stimulation
Heimbürger et al., J Am Soc Nephrol 1997 (Kidney Failure, Chronic) : The aim of the present study was to investigate the role of leptin and its relation to body fat content in chronic renal failure (CRF) , a disorder associated with decreased appetite
Huang et al., Endocrinology 1998 (Body Weight...) : Effects of leptin on corticotropin releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese ( ob/ob ) mice ... Finally, leptin prevented the induction of CRF synthesis in the PVN and the activation of the PVN CRF neurons observed in food deprived ob/ob mice and hindered the elevation of arcuate nucleus neuropeptide Y synthesis in ob/ob mice
Uehara et al., Diabetes 1998 (Anorexia) : Corticotropin releasing hormone (CRH) and neuropeptide Y (NPY), which act in the hypothalamus to influence energy homeostasis, may mediate the anorexic effect of leptin
Antonijevic et al., J Psychiatr Res 1998 : Elevated serum leptin in depression might in turn further promote CRH release, as shown in animals and, hence, contribute to HPA system hyperactivity seen in depression