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JAK3 — LEP

Text-mined interactions from Literome

Carvalheira et al., Biol Chem 2003 : Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase mediated signaling in rat liver
Ishida-Takahashi et al., J Biol Chem 2004 (MAP Kinase Signaling System) : To clarify the molecular mechanism by which GCs rapidly reduce leptin induced JAK/STAT signaling, we examined the intracellular signal transduction pathway potentially mediated by GCs ... PD98059, a specific MEK inhibitor, blocked the inhibitory effects of GCs on leptin induced JAK/STAT activation in Huh7 cells
Laubner et al., Diabetes 2005 (Insulinoma...) : These results suggest that SOCS3 represents a transcriptional inhibitor of preproinsulin gene expression, which is induced by leptin through JAK-STAT3/5b signaling in pancreatic beta-cells ... In conclusion, although SOCS3 is believed to be a negative feedback regulator of JAK-STAT signaling, our findings suggest involvement of SOCS3 in a direct gene regulatory pathway downstream of leptin activated JAK-STAT signaling in pancreatic beta-cells
Leung et al., Kidney Int 2006 : The Janus kinase-signal transducers and activation ( JAK-STAT ) signal transduction pathway in mesothelial cells was activated by either exogenous or adipocytes derived leptin
Abdennebi-Najar et al., The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2011 : Systemically administered PEG-MLA effectively blocks leptin signal induction of hypothalamic JAK-STAT signaling
Zhou et al., Cell Mol Life Sci 2012 (Obesity) : The peptide hormone leptin , produced from adipocytes, activates Jak/Stat3 signaling at the hypothalamus to control food intake, energy expenditure, and fat metabolism
Lu et al., Fish Physiol Biochem 2012 : Overall, our results provided evidence that Lep directly stimulated JAK-STAT signaling mediated lipolysis and fatty acid ß-oxidation gene expression in the fatty degenerated hepatocytes of C. idellus and inhibited the adipogenesis mediated by the IRS-PI(3)K signaling pathway
Pijet et al., Cytokine 2013 (MAP Kinase Signaling System) : Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both JAK/STAT3 and MEK/MAPK but not PI3-K/AKT/GSK-3ß signaling pathways were activated by leptin , and that STAT3 ( Y ( 705 ) P-STAT3 ) and MEK ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) mediate these effects
McCowen et al., Endocrinology 1998 : By contrast, leptin did not increase the phosphorylation of Janus kinase proteins, mitogen activated protein kinase, or STAT1 and -5 despite abundant expression of these signaling molecules in the hypothalamus