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Reiter et al., Thromb Haemost 2003
(Endotoxemia...) :
PAR1 decreased by approximately 8 % ( p < 0.001 ) within 2 h after endotoxin infusion and stayed at those levels until 6 h. Concomitantly,
TRAP induced
P-selectin expression maximally decreased by 18 % ( p < 0.001 ) at 6 h
Patel et al., Platelets 2007
:
Platelet reactivity was evaluated by measuring platelet aggregation, platelet leukocyte aggregates ( PLA ) formation in response to a 6-mer thrombin receptor agonist peptide (TRAP) at a final concentration of 40 microM and flow cytometry determined
P-selectin expression
induced by ADP,
TRAP and arachidonic acid ( AA )
Flaujac et al., Thromb Haemost 2007
(Postoperative Hemorrhage) :
Platelet activation marker expression (
CD62P and activated alphaIIbbeta3 )
induced by ADP or
TRAP was lower after CPB than before CPB, suggesting a deleterious effect of normothermic CPB on platelet function
Chandler et al., Thromb Res 2010
(Coronary Disease) :
Platelet activation by adenosine diphosphate ( ADP ) or
thrombin agonist peptide (TRAP) increased
CD62P and CD40L surface density in the presence of aspirin by 1.9 - 2.8 -fold
Gremmel et al., Translational research : the journal of laboratory and clinical medicine 2013
(Obesity...) :
Finally, PAR-1 mediated platelet activation as assessed by expression of
P-selectin and activated GPIIb/IIIa in
response to
TRAP-6 was significantly more pronounced in obese patients than in patients without obesity ( both P = 0.02 )