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POLDIP2 — RAC1

Text-mined interactions from Literome

Hehner et al., J Biol Chem 2000 : The costimulation induced activation of p38 was inhibited by dominant negative forms of Vav1, Rac , and MKK6
Abell et al., J Cell Sci 2004 : Enhanced binding of Rac2D57N to its upstream regulators would inhibit Rac dependent effects on actin cytoskeletal dynamics and p38 kinase signaling
Saoncella et al., J Biol Chem 2004 : Consistent with the role for Rac1 in activating p38 and JNK signaling, syndecan-4-null cells display higher levels of active p38 MAPK and JNK that were abolished by the expression of a dominant negative RacN17 mutant
Malchinkhuu et al., Oncogene 2005 (Glioma) : Inhibition of Rac1 suppressed JNK but not p38MAPK , while the activity of p38MAPK was abolished by a dominant negative form of Cdc42
Groth et al., J Biol Chem 2005 (Carcinoma...) : Overexpression of wild type Rac1 greatly enhanced the TGF-beta effect on BGN in adherent cells, whereas ectopic expression of constitutively active Rac1 ( Q61L ) activated p38 and in the presence of exogenous TGF-beta was able to rescue BGN expression in nonadherent cells
Zuluaga et al., FEBS Lett 2007 : The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity ... Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum
Westwick et al., Mol Cell Biol 1997 (Cell Transformation, Neoplastic) : Surprisingly, PAK binding was dispensable for Rac1 induced transformation and lamellipodium formation, as well as activation of JNK, p38 , and serum response factor (SRF)
Molnár et al., J Biol Chem 1997 : Furthermore, these results suggest that although both Cdc42Hs and Rac1 can activate p38 in situ, the effects of Cdc42Hs and Rac1 on cell cycle progression are, in fact, quite distinct