Gene interactions and pathways from curated databases and text-mining

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IL2RA — RELA

Text-mined interactions from Literome

Vockerodt et al., Genes Immun 2001 (Burkitt Lymphoma...) : Inhibition of LMP1 mediated NFkappaB enhancement by a constitutive repressive form of IkappaB-alpha resulted in decreased CD25 surface expression, indicating that NFkappaB is involved in CD25 gene regulation
Gruber et al., Mol Immunol 2005 : Consistently, after CD3/CD28 engagement, deficiency of PKCepsilon did not impair NF-kappaB transactivation as well as CD25 , CD44 and CD69 induction
McCaffrey et al., Nucleic Acids Res 1994 : Based on these results, we propose that the NF-kappa B site of the IL2R alpha promoter mediates at least part of the CsA sensitivity of IL2R alpha gene induction in untransformed T cells, possibly because de novo synthesis of p105 NF-kappa B is required for sustained IL2R alpha expression
Pimentel-MuiƱos et al., J Immunol 1994 : Interestingly, a neutralizing anti-TNF-alpha mAb strongly inhibited the proliferation, IL-2R alpha expression, and activation of the nuclear factor (NF)-kappa B induced on human purified T lymphocytes by an immobilized anti-CD3 mAb ( imm.anti-CD3 )