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RELA — SUMO4

Text-mined interactions from Literome

Guo et al., Nat Genet 2004 (Diabetes Mellitus, Type 1...) : SUMO4 conjugates to I kappa B alpha and negatively regulates NF kappa B transcriptional activity
Sedimbi et al., Ann N Y Acad Sci 2006 (Autoimmune Diseases...) : The novel polymorphism M55V, causing an amino acid change in the evolutionarily conserved met55 residue has been shown to activate the nuclear factor kappaB (NF-kappaB) , hence the suspected role of SUMO4 in the pathogenicity of T1DM
Bohren et al., Protein Expr Purif 2007 : The recently identified SUMO4 was detected in mRNA transcripts from HEK293 cells, and human kidney and spleen tissue and may be involved in regulation of NF-kappaB and susceptibility to autoimmune diseases
Wang et al., Biochem Biophys Res Commun 2009 : Previously, we have demonstrated evidence suggesting that SUMO4 negatively regulates NFkappaB transcriptional activity, probably through sumoylation of IkappaBalpha ... Luciferase reporter assays in 3T3 cells deficient for IkappaBalpha further demonstrated that SUMO4 regulates NFkappaB signaling dependent on its sumoylation of IkappaBalpha