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IL1A — SETD2
Text-mined interactions from Literome
Thornton et al., Biochem J 2000
:
In addition,
IL-1 increased the binding of the heterodimer
HIF-1 to the HIF consensus sequence
Stiehl et al., FEBS Lett 2002
:
We investigated whether inhibitors of mitogen activated protein kinase kinases ( MAPKKs : PD 98059, U0126 ) and phosphatidylinositol 3-kinase ( PI3K : LY 294002 ) do not only lower the hypoxia induced, but also the insulin- and
IL-1 induced HIF-1alpha accumulation and
HIF-1 DNA binding in human hepatoma cell cultures ( line HepG2 )
Kannan et al., Am J Physiol Gastrointest Liver Physiol 2011
(Acute Lung Injury...) :
Specifically, partial
HIF-1a deficiency
attenuated SMAO induced increases in intestinal permeability, lipid peroxidation, mucosal caspase-3 activity, and
IL-1ß mRNA levels
Sharma et al., Inflammation 2012
(Neoplasms) :
We have recently reported that Ras acts as an intermediate coactivator in
IL-1ß mediated
hypoxia-inducible factor-1a (HIF-1a) activation in glioblastoma multiforme ( GBM ) ... As we have previously reported that the farnesyltransferase inhibitor manumycin decreases Ras activity in glioma cells, we investigated whether manumycin could regulate
IL-1ß mediated
HIF-1a activation ... Manumycin abrogated
IL-1ß induced
HIF-1a activation in both glioma and non-glioma tumor cells
Sartori-Cintra et al., Clinics (Sao Paulo) 2012
(Osteoarthritis) :
Regulation of
hypoxia-inducible factor-1a (HIF-1a) expression by
interleukin-1ß (IL-1 ß) , insulin-like growth factors I (IGF-I) and II ( IGF-II ) in human osteoarthritic chondrocytes
Bhawal et al., J Cell Biochem 2012
(Bacteroidaceae Infections...) :
Our data strongly suggest that PI-3K-Akt is an upstream participant in
IL-1ß mediated DEC1 and
HIF-1a induction ... This is supported by the following data : ( 1 )
IL-1ß induces 473 serine phosphorylation of Akt; (2) IL-1ß mediated Akt activation occurs in a PI-3K dependent manner, and specific inhibition of PI-3K prevents Akt phosphorylation ; and ( 3 ) inhibition of Akt prevents IL-1ß mediated DEC1 and
HIF-1a induction