Finsterwald et al., J Biol Chem 2010
(MAP Kinase Signaling System) :
Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate ... Together, these data identify a previously unrecognized mechanism by which CREB and the coactivator CRTC1 mediate the effects of BDNF on dendritic growth
Martin et al., Communicative & integrative biology 2011
:
Indeed, we found that the effects of BDNF on dendritic growth of cortical neurons require both the stimulation of cAMP response element binding protein ( CREB ) phosphorylation by BDNF and the activation of the CREB regulated transcription coactivator 1 ( CRTC1 ) by glutamate
Jeong et al., Nat Med 2012
(Disease Models, Animal...) :
Mutant HTT interferes with the TORC1-CREB interaction to repress BDNF transcription, and Sirt1 rescues this defect in vitro and in vivo