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BACE1 — SUMO3
Text-mined interactions from Literome
Dorval et al., Biochem J 2007
:
SUMO3 overexpression also
up-regulated the expression of the transmembrane protease
BACE ( beta-amyloid cleaving enzyme ), but failed to affect levels of several other unrelated proteins
Fang et al., Neuro Endocrinol Lett 2011
:
SUMO negatively
regulates BACE expression ... The
effect of
SUMO on the promoter activity and mRNA expression of
BACE gene was investigated to find the connection between sumoylation and APP processing ... Endogenous
BACE mRNA level was also negatively
regulated by the induction of
SUMO proteins ...
SUMO negatively
regulates the
BACE expression and SP1 is involved in the process