◀ Back to RELA
BCL10 — RELA
Pathways - manually collected, often from reviews:
-
KEGG Tuberculosis:
Complex of BCL10-CARD9-MALT1
→
NFKB1/RELA
(protein-protein, activation)
Text-mined interactions from Literome
Badrichani et al., J Clin Invest 1999
:
In addition, Bcl-2 or
Bcl-XL inhibits activation of
NF-kappaB and thus upregulation of proinflammatory genes
Tamatani et al., J Biol Chem 1999
:
Tumor necrosis factor
induces Bcl-2 and
Bcl-x expression through
NFkappaB activation in primary hippocampal neurons ... Expression of the mutant NFkappaB completely inhibited
NFkappaB DNA binding activity and
inhibited both TNF induced up-regulation of Bcl-2 and
Bcl-x expression and neuroprotective effect
Koseki et al., J Biol Chem 1999
:
Expression of
CIPER induced
NF-kappaB activation, which was inhibited by dominant negative NIK and a nonphosphorylable IkappaB-alpha mutant but not by dominant negative RIP
Zhang et al., Nat Genet 1999
(Lymphoma, B-Cell, Marginal Zone...) :
Wild-type
BCL10 activated
NF-kappaB but induced apoptosis of MCF7 and 293 cells
Costanzo et al., J Biol Chem 1999
:
Expression of
c-E10 under the control of a doxycycline dependent transcriptional transactivator
results in
NF-kappaB activation, which is inhibited by dominant negative forms of TRAF2 and NIK kinase
Lee et al., Proc Natl Acad Sci U S A 1999
(Lymphoma, B-Cell) :
NF-kappaB mediated up-regulation of
Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
Chen et al., J Biol Chem 1999
:
The present study investigated the
involvement of the transcription factor
NF-kappaB in the expression of an anti-apoptotic gene,
bcl-x , using a murine macrophage cell line and peritoneal macrophages from both wild type ( p50 ( +/+ ) ) and NF-kappaB p50 gene knockout ( p50 ( -/- ) ) mice
Chen et al., Mol Cell Biol 2000
:
The expression of
bcl-x suppressed apoptosis in the
presence or absence of
NF-kappaB activity
Tamatani et al., J Neurochem 2000
:
These findings suggest a pathway where
NFkappaB activation
induces overexpression of Bcl-2 and
Bcl-x , which function to prevent apoptotic cell death following H/R treatments
Bertin et al., J Biol Chem 2000
:
BCL10/CLAP is an
activator of apoptosis and
NF-kappaB signaling pathways and has been implicated in B cell lymphomas of mucosa associated lymphoid tissue ... Although its role in apoptosis remains to be determined,
BCL10 likely
activates NF-kappaB through the IKK complex in response to upstream stimuli ... Although its role in apoptosis remains to be determined,
BCL10 likely
activates NF-kappaB through the IKK complex in response to upstream stimuli
Bertin et al., J Biol Chem 2001
:
When expressed in cells, CARD11 and CARD14 activate
NF-kappaB and
induce the phosphorylation of
BCL10
Ravi et al., Nat Cell Biol 2001
:
Inhibition of
NF-kappaB by blocking activation of the IkappaB kinase complex
reduces Bcl-x L expression and sensitizes tumour cells to TRAIL induced apoptosis
Qiu et al., J Neurosci Res 2001
(Hypoxia, Brain) :
Differential
NF-kappa B regulation of
bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia ... The transcription factor
NF-kappa B regulates
bcl-x gene expression ... In this study, we examined the
role of
NF-kappa B in the regulation of
bcl-x in hypoxia induced cell death
Gaide et al., FEBS Lett 2001
(Lymphoma) :
Bcl10 , a caspase recruitment domain ( CARD ) -containing protein identified from a breakpoint in mucosa associated lymphoid tissue ( MALT ) B lymphomas, is
essential for antigen-receptor mediated
nuclear factor kappaB (NF-kappaB) activation in lymphocytes ... Moreover, expression of Carma1 induces phosphorylation of
Bcl10 and
activation of the transcription factor
NF-kappaB
McAllister-Lucas et al., J Biol Chem 2001
(Lymphoma, B-Cell, Marginal Zone) :
Bimp1, a MAGUK family member linking protein kinase C activation to
Bcl10 mediated
NF-kappaB induction ... Bimp1 mediated
NF-kappaB activation
requires Bcl10 and IkappaB kinases, indicating that Bimp1 acts upstream of these mediators
Glasgow et al., Neurochem Res 2001
(Anoxia) :
Transcriptional
regulation of the
BCL-X gene by
NF-kappaB is an element of hypoxic responses in the rat brain
Cao et al., J Tongji Med Univ 2001
:
To explore the
effect of
NF-kappa B on
bcl-x gene transcription in extended drug resistance leukemia cell line HL-60/E6, drug-resistant subline HL-60/E6 was derived by intermittently exposing HL-60 cells to 6 ng/ml epirubicin ... It was concluded that
NF-kappa B was
involved in regulating
bcl-x transcription
Vega et al., Adv Anat Pathol 2001
(Lymphoma, B-Cell, Marginal Zone...) :
Recent work suggests that API2-MALT1 and
BCL-10-MALT1 may
activate NF-kB and a common downstream signaling pathway
Kasof et al., Oncogene 2001
(Prostatic Neoplasms) :
Analysis of several anti-apoptotic proteins revealed that
Bcl-x ( L ) levels and serine 32 phosphorylation of IkappaB, the natural
inhibitor of
NF-kappaB , were similarly elevated in cells expressing high levels of DR6, suggesting that NF-kappaB regulated survival proteins may protect from DR6 induced apoptosis and that DR6 is a target of NF-kappaB regulation
Shou et al., J Neurochem 2002
:
NF-kappaB mediated up-regulation of
Bcl-X ( S ) and Bax contributes to cytochrome c release in cyanide induced apoptosis ...
NF-kappaB , a redox-sensitive transcription factor activated after cyanide treatment, is
responsible for the up-regulation of
Bcl-X ( S ) and Bax ... It was concluded that
NF-kappaB mediated up-regulation of
Bcl-X ( S ) and Bax is involved in regulating cytochrome c release in cyanide induced apoptosis
Stehlik et al., J Biol Chem 2003
:
In transfection experiments, the CARD6 protein suppressed NF-kappa B induction by Nod1 or Cardiak but did not interfere with
NF-kappa B activation by the CARD containing adapter protein
Bcl10 or the cytokine tumor necrosis factor-alpha, demonstrating specificity of CARD6 for Nod-1 and Cardiak dependent pathways
Yorke et al., Eur J Cancer 2003
(Adenocarcinoma...) :
Receptor activator of
NF-kappaB ( RANK ) activation
induces several survival signals including nuclear factor kappaB (NF-kappaB) and activation and upregulation of
Bcl-xL
Ruefli-Brasse et al., J Biol Chem 2004
:
Furthermore, deficiency in
Bcl10 dependent
NF-kappaB activation could be rescued in Rip2-/- embryonic fibroblasts by exogenous wild-type Rip2 but not a kinase-dead mutant
Wang et al., Mol Cell Biol 2004
:
Consistently, expression of a mutant CARMA1, CARMA1 ( DeltaCD ), that can not associate with Bcl10 failed to restore CD3/CD28 costimulation induced NF-kappaB activation in JPM50.6 cells, whereas expression of
Bcl10-CARMA ( DeltaCD ) fusion protein effectively
restored this
NF-kappaB activation
Zhou et al., Nature 2004
(Lymphoma, B-Cell, Marginal Zone) :
Bcl10 is
essential for
NF-kappaB activation by T- and B-cell receptors ...
Bcl10 overexpression is
sufficient to activate
NF-kappaB , a process that requires the NF-kappaB essential modulator NEMO ( also known as IKK-gamma ), which is the regulatory subunit of the IkappaB kinase complex ... Notably, a mutant form of NEMO that can not be ubiquitinated inhibited
Bcl10 induced
NF-kappaB activation ... Paracaspase and a ubiquitin conjugating enzyme ( UBC13 ) were both required for
Bcl10 induced NEMO ubiquitination and subsequent
NF-kappaB activation ... Thus, the adaptor protein
Bcl10 promotes activation of
NF-kappaB transcription factors through paracaspase- and UBC13 dependent ubiquitination of NEMO
Scharschmidt et al., Mol Cell Biol 2004
:
Degradation of
Bcl10 induced by T-cell activation negatively
regulates NF-kappa B signaling
Stilo et al., J Biol Chem 2004
:
Expression of the NEMO binding region of CARMA3 exerts a dominant negative effect on
Bcl10 mediated activation of
NFkappaB
Chen et al., Apoptosis 2004
(Colonic Neoplasms) :
Bcl-2, and to the less extent,
Bcl-xL , were able to
increase the activity of
NF-kappa B , which was a known anti-apoptotic molecule in human colon cancer cells
Hosokawa et al., Int J Hematol 2004
(Lymphoma, B-Cell, Marginal Zone) :
Recent genetic and biochemical studies have indicated that
BCL10 and MALT1 form a physical and functional complex and are both
essential for
nuclear factor kappaB (NF-kappaB) activation by antigen receptor stimulation in lymphocytes
Tran et al., J Biol Chem 2005
(Astrocytoma...) :
In addition, Fn14 activation induced
BCL-XL and BCL-W mRNA and protein levels, and this effect was
dependent upon
NFkappaB transcriptional activity ... Our results suggest that
NFkappaB mediated up-regulation of BCL-XL and
BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy induced apoptosis
Woo et al., FEBS Lett 2004
:
Inhibition of
Bcl10 mediated
activation of
NF-kappa B by BinCARD, a Bcl10 interacting CARD protein ... BinCARD potently suppressed
NF-kappa B activation
induced by
Bcl10 and decreased the amounts of phosphorylated Bcl10 ... Mutations at the residue Leu17 or Leu65, which is highly conserved in CARD, abolished the inhibitory effects of BinCARD on both
Bcl10 induced
activation of
NF-kappa B and phosphorylation of Bcl10 ... These results suggest that BinCARD interacts with Bcl10 to inhibit
Bcl10 mediated activation of
NF-kappa B and to suppress Bcl10 phosphorylation
Ye et al., J Pathol 2005
(Lymphoma, B-Cell, Marginal Zone...) :
The oncogenic activity of the three chromosomal translocations is linked by the physiological
role of
BCL10 and MALT1 in antigen receptor mediated
NFkappaB activation
Hosokawa et al., Apoptosis 2005
(Lymphoma, B-Cell, Marginal Zone...) :
Recent biochemical and genetic studies have clearly shown that
BCL10 and MALT1 form a physical and functional complex and are both
required for
NF-kappaB activation by antigen receptor stimulation in T and B lymphocytes
Tian et al., Blood 2005
(Lymphoma, B-Cell) :
Induction of
Bcl10 activity
caused rapid activation of
nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK), but not activation of extracellular signal regulated kinase ( ERK ) or p38 mitogen activated protein ( MAP ) kinases
Nakamura et al., Pathobiology 2005
:
The dysregulated overexpression of
BCL10 that results from a specific chromosomal translocation t ( 1 ; 14 ) ( p22 ; q32 ) in mucosa associated lymphoid tissue lymphoma has been shown to
activate nuclear factor (NF)-kappaB , which may promote growth and survival in tumor cells ... The aim of this study was to determine the molecular mechanisms underlying
NF-kappaB activation by
BCL10 overexpression ... Furthermore, the
BCL10 mediated
NF-kappaB activation was efficiently inhibited by a Ca2+ chelating agent or a Ca2+ channel blocker ... These findings suggest that the filamentous pattern of overexpressed BCL10 at the perinuclear region adjacent to the endoplasmic reticulum is important for the
BCL10 mediated
NF-kappaB activation
Hu et al., J Clin Invest 2006
(Lymphoma, B-Cell, Marginal Zone...) :
While both
BCL10 and MALT1 are critically
involved in antigen receptor mediated
NF-kappaB activation, the role of cIAP2 is not clear ... Furthermore,
BCL10 and cIAP2-MALT1 synergistically
activate NF-kappaB ... Furthermore,
BCL10 and cIAP2-MALT1 synergistically
activate NF-kappaB
Tao et al., Mol Cell Biol 2006
:
Up-regulation of proapoptotic protein
Bcl-XS and neuronal apoptosis induced by serum deprivation are
blocked by inhibition and/or down-regulation of
NF-kappaB and by prevention of K+ loss
Nakagawa et al., Leukemia 2006
(Lymphoma, B-Cell, Marginal Zone) :
Several lines of evidence indicated that both
BCL10 and MALT1 are
required for
nuclear factor kappa B (NF-kappaB) activation by antigen receptor stimulation in lymphocytes, and API2-MALT1 can bypass this BCL10/MALT1 signaling pathway
Rivera et al., Trends Immunol 2006
:
The
CARMA1-Bcl10-Malt1 adaptor complex
regulates NFkappaB activation by antigen receptors in lymphocytes
Hu et al., Cell cycle (Georgetown, Tex.) 2006
:
Furthermore, cIAP2-MALT1 and
Bcl10 synergistically
activate NF-kappaB
Ishiguro et al., Mol Cell Biol 2006
:
CARMA1 and
Bcl10 functionally interact and
control NF-kappaB signaling downstream of the T-cell receptor ( TCR )
Gross et al., Nature 2006
:
Card9 couples to Bcl10 and regulates
Bcl10-Malt1 mediated
NF-kappaB activation induced by zymosan
Khanbolooki et al., Mol Cancer Ther 2006
(Pancreatic Neoplasms) :
NF-kappaB inhibition
resulted in down-regulation of
BCL-XL and XIAP, and silencing either restored TRAIL sensitivity in TRAIL-resistant cells
Ishiguro et al., Mol Immunol 2007
:
S138A mutation prolongs
Bcl10 induced
NF-kappaB activation, suggesting that Bcl10 phosphorylation is involved in attenuation of NF-kappaB activation
Klemm et al., Proc Natl Acad Sci U S A 2007
:
Bcl10 and Malt1
control lysophosphatidic acid induced
NF-kappaB activation and cytokine production ... By using murine embryonic fibroblasts from Bcl10- or Malt1-deficient mice as a genetic model, we report that
Bcl10 and Malt1 are critically
required for the degradation of IkappaB-alpha and the subsequent
NF-kappaB induction in response to LPA stimulation
McAllister-Lucas et al., Proc Natl Acad Sci U S A 2007
(Inflammation) :
CARMA3/Bcl10/MALT1 dependent
NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells
Wang et al., Proc Natl Acad Sci U S A 2007
:
Bcl10 plays a critical role in
NF-kappaB activation induced by G protein coupled receptors
Jost et al., J Immunol 2007
:
Bcl10/Malt1 signaling is
essential for TCR induced
NF-kappaB activation in thymocytes but dispensable for positive or negative selection
Deeb et al., J Pharmacol Exp Ther 2007
(Prostatic Neoplasms) :
Because expression of antiapoptotic Bcl-2,
Bcl-xL , and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is
regulated by
NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB
Kunnumakkara et al., Cancer Res 2007
(Neovascularization, Pathologic...) :
In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ),
NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2,
Bcl-xL , cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Wegener et al., Science's STKE : signal transduction knowledge environment 2007
:
CARD11 ( CARMA1 ),
Bcl10 , and Malt1 are
required for nuclear factor
NF-kappaB activation in response to antigen recognition
Hara et al., Nat Immunol 2007
(Listeriosis) :
The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells ... The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Zeng et al., Mol Cell Biol 2007
:
Phosphorylation of
Bcl10 negatively
regulates T-cell receptor mediated
NF-kappaB activation ...
Bcl10 plays a critical role in antigen receptor mediated
NF-kappaB activation and lymphocyte development and functions
Ferch et al., Nat Immunol 2007
:
Here we found that
Bcl-10 and MALT1 differentially regulated B cell receptor
induced activation of
RelA and c-Rel
Takase et al., Kidney Int 2008
(Chronic Disease...) :
Inhibition of
NF-kappaB dependent
Bcl-xL expression by clusterin promotes albumin induced tubular cell apoptosis
Lee et al., Int J Cancer 2008
(Carcinoma, Squamous Cell...) :
A signal network
involving coactivated
NF-kappaB and STAT3 and altered p53 modulates
BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Aimbire et al., Int Immunopharmacol 2008
(Inflammation) :
LLLT and an inhibitor of
NF-kappaB nuclear translocation ( BMS 205820 )
attenuated the mRNA levels of
Bcl-xL and A1 mRNA in lung neutrophils obtained from mice subjected to LPS induced inflammation
Stilo et al., J Cell Sci 2008
:
A20 is a negative regulator of
BCL10- and CARMA3 mediated
activation of
NF-kappaB
Hara et al., J Immunol 2008
:
Although the caspase recruitment domain
(CARD)9-Bcl10 complex is
essential for FcRgamma/DAP12 mediated
NF-kappaB activation in myeloid cells, its involvement in NK cell receptor signaling is unknown
Travert et al., J Immunol 2008
(Lymphoma, Follicular) :
Thus, the antiapoptotic signaling of CD40, which interferes with TRAIL induced apoptosis in FL B cells, involves
NF-kappaB mediated induction of c-FLIP and
Bcl-x ( L ) which can respectively interfere with caspase 8 activation or mitochondrial mediated apoptosis
Kuo et al., Blood 2008
(Lymphoma, B-Cell, Marginal Zone...) :
In B-cell lymphoma Pfeiffer cells, BAFF activated NF-kappaB and AKT ; the activated
NF-kappaB up-regulated
BCL10 , and the activated AKT caused formation of BCL10/BCL3 complexes that translocated to the nucleus
Takeda et al., Int Immunol 2008
:
In addition, we found that
Bcl10 induced
NF-kappaB activation through CD28 mediated stimulation could be blocked by the dominant negative form of PKC or CARMA1
Kingeter et al., J Immunol 2008
:
Loss of protein kinase C theta,
Bcl10 , or Malt1 selectively
impairs proliferation and
NF-kappa B activation in the CD4+ T cell subset
Ghosh-Choudhury et al., Breast Cancer Res Treat 2009
(Adenocarcinoma...) :
NFkappaB DNA binding activity and
NFkappaB dependent transcription of Bcl-2 and
Bcl-XL genes were also prevented by DHA and EPA treatment ... Finally, we showed that PTEN expression significantly inhibited
NFkappaB dependent transcription of Bcl-2 and
Bcl-XL genes
Bhattacharyya et al., Inflamm Bowel Dis 2009
:
DSS induced increases in phospho-IkappaBalpha, nuclear
NFkappaB ( p65 ), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species ( ROS ) -induced pathway of inflammation, and do not
require TLR4, MyD88, or
Bcl10 , which are associated with the innate immune pathway of NFkappaB-IL-8 activation
Goodridge et al., J Immunol 2009
:
A recent report identified a role for CARD9 in innate anti-fungal responses, demonstrating
CARD9-Bcl10 mediated activation of
NF-kappaB and proinflammatory cytokine induction in murine bone marrow derived DC stimulated via Dectin-1
Lomonaco et al., DNA Cell Biol 2009
(Xeroderma Pigmentosum) :
Given the important function of NF-kappaB in regulating transcription of the bcl-x ( l ) gene and the Bcl-x ( L ) protein in preventing apoptosis, these results suggest that NER may protect cells against cisplatin induced apoptosis by activating
NF-kappaB , which further
induces transcription of the
bcl-x ( l ) gene, resulting in an accumulation of Bcl-x ( L ) protein and activation of the cell survival pathway that leads to increased cell survival under cisplatin treatment
Banerjee et al., Cancer Res 2009
(Pancreatic Neoplasms) :
Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down-regulation of constitutive as well as drug induced
activation of
NF-kappaB and its downstream genes (
Bcl-xL , XIAP, cIAP, and survivin )
Marasco et al., Biochem J 2009
:
When tested in cell assays for its capacity to block NF-kappaB activation, this peptide represses activation of
NF-kappaB mediated by
BCL10 , CARMA3 and PMA/ionomycin stimulation
Borthakur et al., Inflamm Bowel Dis 2010
:
Bcl10 was
required for PAF induced I kappaB alpha phosphorylation,
NF-kappaB activation, and IL-8 production in NCM460, a cell line derived from normal human colon, and Caco-2, a transformed human intestinal cell line
Chan et al., J Pathol 2010
(Lymphoma, Extranodal NK-T-Cell) :
Interleukin-2
induces NF-kappaB activation through
BCL10 and affects its subcellular localization in natural killer lymphoma cells
Jinawath et al., PloS one 2010
(Ovarian Neoplasms) :
Combined ectopic expression of
RELA and STAT5B
enhanced Bcl-xL promoter activity while treatment with BMS-345541 and Dasatinib decreased it
Van Beek et al., Cell reports 2012
(Carcinoma, Hepatocellular...) :
Here, we demonstrate that the saturated FA, palmitate,
requires Bcl10 for
NF-kB activation in hepatocytes ... Surprisingly, while CARMA3 also participates in the palmitate response, MALT1 is completely dispensable, thereby revealing an apparent nonclassical
role for
Bcl10 in
NF-kB signaling
Paul et al., Autophagy 2012
:
Protecting
BCL10 from autophagic degradation, either by pharmacological or genetic inhibition of autophagy,
results in increased activation of
NFKB1-RELA
Zhang et al., Mol Cell Biol 1994
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
In contrast to I kappa B alpha ( MAD3 ),
BCL3 does not
cause NF-kappa B p50 to be retained in the cytoplasm ; instead, in cotransfection assays, it alters the subnuclear localization of p50
Dixon et al., Brain Res 1997
(Ischemic Attack, Transient) :
In this study, we show that
NF-kB p50 and NF-kB p65 act in synergy to
transactivate the
bcl-x promoter in co-transfected 293 cells ... These results suggest that activation of
NF-kB can
lead to increased expression of
bcl-x as manifested by the increase in the short form of bcl-x
Willis et al., Cell 1999
(Cell Transformation, Neoplastic...) :
Bcl10 and E10
activated NF-kappaB but caused apoptosis of 293 cells ... Truncated
Bcl10 activated
NF-kappaB but did not induce apoptosis