◀ Back to IL8
CXCR1 — IL8
Pathways - manually collected, often from reviews:
-
KEGG Epithelial cell signaling in Helicobacter pylori infection:
IL8
→
CXCR1/CXCR2
(protein-protein, activation)
-
KEGG Cytokine-cytokine receptor interaction:
IL8
→
CXCR1
(protein-protein, activation)
-
KEGG Chemokine signaling pathway:
CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2
→
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
(protein-protein, activation)
-
Reactome Reaction:
CXCR1
→
IL8
(reaction)
Holmes et al., Science 1991*, Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Matsushima et al., J Exp Med 1988*, Takami et al., Brain Res Mol Brain Res 1994, Rovai et al., J Immunol 1997*
-
Reactome Reaction:
CXCR1
→
IL8
(direct_complex)
Holmes et al., Science 1991*, Matsushima et al., J Exp Med 1988*, Rovai et al., J Immunol 1997*
Text-mined interactions from Literome
Suetomi et al., J Biol Chem 1999
:
This study demonstrates that
IL-8 recognizes and
activates CXCR1,
CXCR2 , and the Duffy antigen by distinct mechanisms ... This study demonstrates that
IL-8 recognizes and
activates CXCR1 , CXCR2, and the Duffy antigen by distinct mechanisms
Barlic et al., J Biol Chem 1999
:
beta-arrestins regulate
interleukin-8 induced
CXCR1 internalization
Hauser et al., Shock 1999
(Calcium Signaling...) :
CXCR2 stimulation primes
CXCR1 [Ca2+ ] i
responses to
IL-8 in human neutrophils
Williams et al., Arch Surg 1999
(Postoperative Complications...) :
Flow cytometry and radioligand binding data indicate that
IL-8 , GCP-2, and ENA-78 equivalently
reduced CXCR-1 and CXCR-2 cell surface expression by 34 % to 54 %
Venkatakrishnan et al., J Biol Chem 2000
(Ovarian Neoplasms) :
Stimulation of the
CXCR-1/2 receptors by human
interleukin 8 (IL-8) rapidly activated the p44/42 mitogen activated protein ( extracellular signal regulated kinase ( Erk1/2 ) ) kinase pathway
Zaslaver et al., J Immunol 2001
:
Nocodazole, a microtubule disrupting agent, did not affect the
IL-8 induced reduction in cell surface expression of
CXCR1 and CXCR2, nor did it affect the recycling of these receptors following ligand removal and cell recovery at 37 degrees C ... In contrast, cytochalasin D, an actin filament depolymerizing agent, promoted the
IL-8 induced reduction in cell surface expression of both
CXCR1 and CXCR2
Schraufstatter et al., Am J Physiol Lung Cell Mol Physiol 2001
:
IL-8 activates endothelial cell
CXCR1 and CXCR2 through Rho and Rac signaling pathways ... These results indicate that
IL-8 activates both the
CXCR1 and the CXCR2 on microvascular endothelial cells, using different signal transduction cascades
Venuprasad et al., Eur J Immunol 2001
:
Thus, our results demonstrate for the first time that CD28 is expressed on human peripheral blood neutrophils and that CD28 may play an important role in the regulation of
IL-8RA expression and migration of neutrophils in
response to
IL-8
Adams et al., J Trauma 2001
(Pneumonia...) :
Such outcomes have been related to excess production of the CXC chemokine
interleukin (IL)-8 , but PMN responses to IL-8 are
mediated by both the relatively stable and IL-8 specific
CXC receptor 1 (CXCR1) and the labile, promiscuous CXCR2
Puma et al., J Neurochem 2001
:
Our results suggest that
IL-8 release by glial cells in vivo may
activate CXCR1 and CXCR2 receptors on cholinergic septal neurons and acutely modulate their excitability by closing calcium channels
Feniger-Barish et al., Biochemistry 2003
(Inflammation) :
CXCR1 and CXCR2 mediate migratory activities in
response to
IL-8 and other ELR+-CXC chemokines ( e.g., GCP-2 and NAP-2 )
Ramjeesingh et al., FASEB J 2003
(Melanoma) :
Interleukin-8 secreted by endothelial cells
induces chemotaxis of melanoma cells through the chemokine receptor
CXCR1
Zhu et al., Br J Cancer 2004
(Carcinoma, Non-Small-Cell Lung...) :
In conclusion,
IL-8 can act as an autocrine and/or paracrine growth factor for lung cancer cells, and the mitogenic function of IL-8 in lung cancer is
mediated mainly by
CXCR1 receptor
Tseng-Rogenski et al., American journal of physiology. Renal physiology 2009
(Cystitis, Interstitial) :
This rescue effect could be blocked by antibodies to the IL-8 receptor CXCR1 but not by CXCR2, suggesting that normal urothelial cells normally have
IL-8 autocrine or paracrine activity for survival and growth
mediated by
CXCR1
Chen et al., Hum Reprod 2010
(Ascites...) :
IL-8 activated
CXCR1/2 of endothelial cells leading to VEGF receptor (VEGFR)-2 transactivation
Gras et al., Int Arch Allergy Immunol 2010
:
The present study illustrated the fact that
IL-8 mediated by
CXCR-1 increased IL-6
Snoussi et al., BMC cancer 2010
(Breast Neoplasms...) :
IL-8 acts through its
CXCR1 and CXCR2 receptors
Agarwal et al., Cancer Res 2010
(Neovascularization, Pathologic...) :
The secreted
IL-8 and GRO-alpha
acts on endothelial
CXCR1/2 receptors in a paracrine manner to cause robust endothelial cell proliferation, tube formation, and migration