Gene interactions and pathways from curated databases and text-mining

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CXCR1 — IL8

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Suetomi et al., J Biol Chem 1999 : This study demonstrates that IL-8 recognizes and activates CXCR1, CXCR2 , and the Duffy antigen by distinct mechanisms ... This study demonstrates that IL-8 recognizes and activates CXCR1 , CXCR2, and the Duffy antigen by distinct mechanisms
Barlic et al., J Biol Chem 1999 : beta-arrestins regulate interleukin-8 induced CXCR1 internalization
Hauser et al., Shock 1999 (Calcium Signaling...) : CXCR2 stimulation primes CXCR1 [Ca2+ ] i responses to IL-8 in human neutrophils
Williams et al., Arch Surg 1999 (Postoperative Complications...) : Flow cytometry and radioligand binding data indicate that IL-8 , GCP-2, and ENA-78 equivalently reduced CXCR-1 and CXCR-2 cell surface expression by 34 % to 54 %
Venkatakrishnan et al., J Biol Chem 2000 (Ovarian Neoplasms) : Stimulation of the CXCR-1/2 receptors by human interleukin 8 (IL-8) rapidly activated the p44/42 mitogen activated protein ( extracellular signal regulated kinase ( Erk1/2 ) ) kinase pathway
Zaslaver et al., J Immunol 2001 : Nocodazole, a microtubule disrupting agent, did not affect the IL-8 induced reduction in cell surface expression of CXCR1 and CXCR2, nor did it affect the recycling of these receptors following ligand removal and cell recovery at 37 degrees C ... In contrast, cytochalasin D, an actin filament depolymerizing agent, promoted the IL-8 induced reduction in cell surface expression of both CXCR1 and CXCR2
Schraufstatter et al., Am J Physiol Lung Cell Mol Physiol 2001 : IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways ... These results indicate that IL-8 activates both the CXCR1 and the CXCR2 on microvascular endothelial cells, using different signal transduction cascades
Venuprasad et al., Eur J Immunol 2001 : Thus, our results demonstrate for the first time that CD28 is expressed on human peripheral blood neutrophils and that CD28 may play an important role in the regulation of IL-8RA expression and migration of neutrophils in response to IL-8
Adams et al., J Trauma 2001 (Pneumonia...) : Such outcomes have been related to excess production of the CXC chemokine interleukin (IL)-8 , but PMN responses to IL-8 are mediated by both the relatively stable and IL-8 specific CXC receptor 1 (CXCR1) and the labile, promiscuous CXCR2
Puma et al., J Neurochem 2001 : Our results suggest that IL-8 release by glial cells in vivo may activate CXCR1 and CXCR2 receptors on cholinergic septal neurons and acutely modulate their excitability by closing calcium channels
Feniger-Barish et al., Biochemistry 2003 (Inflammation) : CXCR1 and CXCR2 mediate migratory activities in response to IL-8 and other ELR+-CXC chemokines ( e.g., GCP-2 and NAP-2 )
Ramjeesingh et al., FASEB J 2003 (Melanoma) : Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1
Zhu et al., Br J Cancer 2004 (Carcinoma, Non-Small-Cell Lung...) : In conclusion, IL-8 can act as an autocrine and/or paracrine growth factor for lung cancer cells, and the mitogenic function of IL-8 in lung cancer is mediated mainly by CXCR1 receptor
Tseng-Rogenski et al., American journal of physiology. Renal physiology 2009 (Cystitis, Interstitial) : This rescue effect could be blocked by antibodies to the IL-8 receptor CXCR1 but not by CXCR2, suggesting that normal urothelial cells normally have IL-8 autocrine or paracrine activity for survival and growth mediated by CXCR1
Chen et al., Hum Reprod 2010 (Ascites...) : IL-8 activated CXCR1/2 of endothelial cells leading to VEGF receptor (VEGFR)-2 transactivation
Gras et al., Int Arch Allergy Immunol 2010 : The present study illustrated the fact that IL-8 mediated by CXCR-1 increased IL-6
Snoussi et al., BMC cancer 2010 (Breast Neoplasms...) : IL-8 acts through its CXCR1 and CXCR2 receptors
Agarwal et al., Cancer Res 2010 (Neovascularization, Pathologic...) : The secreted IL-8 and GRO-alpha acts on endothelial CXCR1/2 receptors in a paracrine manner to cause robust endothelial cell proliferation, tube formation, and migration