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CDKN1A — NGF

Text-mined interactions from Literome

Bulseco et al., J Cell Biochem 2001 : NGF induced p21 ( WAF1 ) expression, cell-cycle arrest and process extension are abolished by N-nitro-L-arginine methyl ester ( L-NAME ), a competitive inhibitor of NOS
Seo et al., Neuroreport 2003 : NGF repressed the induction of p21WAF1 , cyclin dependent kinase (CDK) inhibitor, in L61Cdc42 transfected PC12 cells, whereas NGF induced the expression of p21WAF1 in other PC12 cell lines
Muroya et al., Biochim Biophys Acta 1992 (Adrenal Gland Neoplasms...) : Herbimycin and genistein blocked NGF dependent activation of ras p21 whose essential function in neuronal differentiation has been reported
Muroya et al., Oncogene 1992 : Interestingly, the protein kinase inhibitor K-252a specifically suppressed the NGF induced accumulation of p21-GTP , but did not suppress the EGF induced response
Decker et al., J Biol Chem 1995 : These data indicate that NGF can induce cell cycle arrest of NIH-3T3, perhaps through modulation of p21Cip1/WAF1 levels
Billon et al., Oncogene 1996 (Pheochromocytoma) : Transient expression of a mutated form of the adenovirus E1A protein ( E1A dCR2 ), which retains its capacity to bind the transcriptional co-activator p300, completely abolishes the NGF mediated stimulation of p21 promoter activity ... This phenomenon can be reversed by ectopic expression of p300, suggesting that p300 is necessary for the induction of p21 by NGF
Pumiglia et al., Proc Natl Acad Sci U S A 1997 : PD98059 also blocked the ability of NGF to inhibit the activities of CDK4 and CDK2, while partially preventing NGF induction of p21Cip1/WAF1
Tombes et al., Biochem J 1998 : Ethanol and NGF co-treatment increased expression of p21 ( Cip-1/WAF1 ) and p16(INK4a) cdk inhibitor proteins and decreased hepatocyte DNA synthesis