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ICAM2 — TNF
Text-mined interactions from Literome
McLaughlin et al., Cell adhesion and communication 1998
(Inflammation) :
We have studied the
effect of
TNF-alpha and IL-1beta on
ICAM-2 expression on human umbilical vein endothelial cells ( HUVECs )
Bleijs et al., Eur J Immunol 1999
:
In contrast,
ICAM-2 and ICAM-3
induced a much stronger secretion of the Th1 cytokine
TNF-alpha compared to LFA-1/ICAM-1 induced co-stimulation, despite the lower proliferation rate
Langley et al., Am J Physiol 1999
(Neoplasms, Experimental...) :
The dual radiolabeled monoclonal antibody technique was used to quantify constitutive and
tumor necrosis factor (TNF)-alpha induced expression of intercellular adhesion molecule 1 ( ICAM-1 ), vascular cell adhesion molecule 1 ( VCAM-1 ),
ICAM-2 , P-selectin, E-selectin, and platelet-endothelial cell adhesion molecule 1 ( PECAM-1 ) in different vascular beds of normal ( C57Bl/6 ) and RM-1 tumor bearing mice
Walther et al., Int J Radiat Biol 1999
:
Treatment with NAC clearly restrained
TNF-alpha induced
ICAM expression on HUVEC, while preincubation of cells with PDTC showed synergistic effects
De Caterina et al., Am J Clin Nutr 2000
(Arteriosclerosis) :
Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin,
intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in
response to IL-1, IL-4,
tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Furukawa et al., J Vasc Surg 2000
:
Finally, the specificity of the effect of transduction of ICP47 on vascular cell MHC-I expression was confirmed by a lack of significant change in either constitutive or
tumor necrosis factor induced vascular cell adhesion
molecule/intercellular adhesion molecule expression
Gnant et al., Cytokine 2000
:
TNF caused increased secretion of IL-6, IL-8,
ICAM-1 , and VCAM-1 with little or no additional effect from HT. Increased E-selectin and RANTES levels were observed with TNF and HT only at 24 h after treatment
Grünberg et al., Tumour Biol 2000
(Breast Neoplasms) :
Furthermore, CEA,
ICAM-1 and CD44v6 were
increased by
TNF-alpha plus calcitriol
McLaughlin et al., Blood 2001
:
It has recently been shown that the transcription factor Erg, an Ets family member, drives constitutive expression of the
intercellular adhesion molecule 2 ( ICAM-2 ) in human umbilical vein endothelial cells ( HUVECs ) and that its expression is
down-regulated by the pleiotropic cytokine
tumor necrosis factor alpha (TNF-alpha)
Bouhlal et al., J Fr Ophtalmol 2002
:
On TNFalpha activated HUVECs, NAAGA induced a significant decrease in the VCAM-1 expression level ( P < 0.0001 ) and totally reversed
TNFalpha induced overexpression of ICAM-1 ( P=0.0069 ),
ICAM-2 and ELAM-1 ( P < 0.0001 ), without interfering with baseline expression of these molecules
Myers et al., Am J Physiol 1992
:
We conclude from these data that although PMA induced ICAM-1 expression may be triggered through activation of protein kinase C,
ICAM-1 induction by IL-1 beta,
TNF-alpha , or LPS may involve distinct regulatory pathway ( s )
Möst et al., J Immunol 1992
:
In contrast,
ICAM-1 expression on two of the three cell lines ( KG1 and HL60 ) was
inducible by
TNF-alpha to a much higher degree than by IFN-gamma, whereas the results with U937 were comparable with those obtained for normal monocytes
Mattila et al., Scand J Immunol 1992
:
TNF alpha induced expression of endothelial adhesion molecules,
ICAM-1 and VCAM-1, is linked to protein kinase C activation
Sabatini et al., Immunol Lett 2003
:
Fluticasone propionate, at the two concentrations tested ( 10 and 100 nM ), was more effective in inhibiting the ` IL-4 plus
TNF-alpha induced
' ICAM-1 expression than VCAM-1 expression ( P < 0.05 ) and in downregulating RANTES than IL-8 or GM-CSF secretion ( P < 0.05 )
Dvorin et al., J Heart Valve Dis 2003
:
HPVEC express E-selectin,
ICAM-1 , and VCAM-1 in
response to the inflammatory cytokine
tumor necrosis factor-alpha (TNF-alpha) similarly to other types of cultured human endothelial cells
VandenBerg et al., J Cell Biochem 2004
:
TNF-alpha increased VCAM-1,
ICAM-1 , and E-selectin by 4 h but had no affect on the expression of PECAM
Choi et al., J Nutr 2004
:
TNF-alpha significantly
induced HUVEC protein expression of VCAM-1,
ICAM-1 , and E-selectin with increasing mRNA levels
Huang et al., Carcinogenesis 2004
(Neoplasm Invasiveness) :
In Matrigel assays,
ICAM-1 and COX-2 expressions
induced by
TNF-alpha elicited A549 and NCI-H292 cell invasion, respectively, and these effects were inhibited by both compounds
Jiang et al., Life Sci 2004
:
The mRNA expression of E-selectin,
ICAM-1 and VCAM-1, and activation of NF-kappaB
induced by
TNF-alpha for 2 h were significantly decreased by the above two pretreatments
Costa et al., Xenotransplantation 2004
:
We first evaluated by flow cytometry the pTNFR1Ig capacity to prevent
TNF alpha induced expression of SLAI, SLAII, VCAM-1,
ICAM-1 and E-selectin on the cell surface of porcine aortic endothelial cells ( PAEC )
Zhang et al., J Am Soc Nephrol 2005
:
This hypothesis was examined further by
stimulation of PTC
ICAM expression by
TNF-alpha ... Although stimulation of PTC by BMP-7 alone decreased cell surface ICAM expression, it did not affect
TNF-alpha induced
ICAM expression
Harada et al., Nephron. Experimental nephrology 2005
:
In these cells,
ICAM-1 and E-selectin expression was
up-regulated by
TNF-alpha , as in native cultured HGEC
Stangl et al., J Nutr 2005
:
Phloretin prevented
TNF-alpha stimulated upregulation of VCAM-1,
ICAM-1 , and E-selectin expression in a concentration dependent manner
Sasaki et al., BMC physiology 2005
:
Trogliazone ( 20 microM ) reduced
TNF-alpha induced VCAM-1,
ICAM-1 and E-selectin expression
Jiang et al., Respir Med 2005
:
The mRNA expression of E-selectin,
ICAM-1 and VCAM-1, and activation of NF-kappaB
induced by
TNF-alpha for 2 h were decreased significantly by the above two pretreatments
Ogawara et al., Arthritis Res Ther 2006
:
RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed, leading to complete abolishment of
TNF-alpha induced up-regulation of E-selectin,
ICAM-1 , VCAM-1, IL-6, IL-8, VEGF-A and Tie-2
Mo et al., J Ethnopharmacol 2007
:
Evidence presented in this report demonstrated that CML-1 inhibited the adhesive capacity of HUVEC and the
TNF-alpha mediated induction of E-selectin,
ICAM-1 and VCAM-1 in HUVEC by inhibiting the IkB/NF-kB signaling pathway at the level of IkB kinase, which may explain the ability of CML-1 to suppress inflammation and modulate the immune response
Conover et al., Growth Horm IGF Res 2008
:
TNF-alpha induced VCAM,
ICAM , and MCP-1 expression ( 4h ) preceded PAPP-A expression ( 24h )
Seldon et al., J Immunol 2007
(Inflammation) :
Basal and
TNF induced expression of VCAM-1,
ICAM-1 , and E-selectin were increased in Hmox1 ( -/- ) vs Hmox1 ( +/+ ) EC, an effect reversed by Fe chelation using deferoxamine mesylate ( DFO )
Hung et al., Eur J Pharmacol 2008
:
Taken together, we provided here the first evidence showing that lycopene is able to inhibit
TNF-alpha induced NF-kappaB activation,
ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases
Winterbone et al., Atherosclerosis 2009
:
Quercetin was able to reduce
TNFalpha induced upregulation of VCAM-1,
ICAM-1 and MCP-1 at both the protein and transcript ( mRNA ) level in HUASMC
Wang et al., J Perinatol 2009
(Pre-Eclampsia) :
( 1 ) TNFalpha induced dose dependent increases in ICAM, VCAM and E-selectin expressions in endothelial cells ; ( 2 ) Digibind could attenuate and reduce
TNFalpha induced
upregulation of endothelial E-selectin,
ICAM and VCAM expressions
Ming et al., BMC cardiovascular disorders 2009
:
The
induction of the expression of endothelial VCAM-1,
ICAM-1 and E-selectin by
TNFalpha was concentration-dependently reduced by incubation of the endothelial cells with the arginase inhibitor L-norvaline
Yu et al., J Agric Food Chem 2010
:
Induction of heme oxygenase 1 and inhibition of
tumor necrosis factor alpha
induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells
Chen et al., Vascul Pharmacol 2011
:
ZLJ-6, a novel COX/5-LOX inhibitor, attenuates
TNF-a induced endothelial E-selectin,
ICAM-1 and VCAM-1 expression and monocyte-endothelial interactions via a COX/5-LOX independent mechanism
Escobar et al., Biochem Pharmacol 2012
(Pancreatitis, Acute Necrotizing) :
Oxidative stress significantly contributes to the
TNF-a induced up-regulation of
Icam and iNos in AR42J cells
Khanicheh et al., J Am Soc Echocardiogr 2012
:
To assess in vivo attachment efficiency to endothelial counterligands that vary in their distance from the endothelial cell surface, contrast enhanced ultrasound ( CEU ) molecular imaging of
tumor necrosis factor-a induced P-selectin ( long distance ) or
intercellular adhesion molecule-2 ( short distance ) was performed with each agent in murine hind limbs
Xing et al., Pharm Biol 2013
:
In addition, the effects of total flavonoids on inflammatory molecule expression of cells were tested by immunohistochemistry staining, showing that
TNF-a induced expression of PCNA, NF-?B p65,
ICAM-1 , and VCAM-1 in VSMCs was dose-dependently suppressed by total flavonoids
Kong et al., Lipids in health and disease 2013
:
However, comparing to the model rabbits, levels of
TNF-a , IL-1ß and MDA decreased significantly and serum SOD activity
increased , gene and protein expressions of E-sel,
ICAM-1 , VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol
Tang et al., Am J Physiol 1995
:
In conclusion, 1 ) CD11a,
ICAM-1 , and CINC play major roles in the LPS initiated emigration of PMNs into the bronchoalveolar space, and 2 ) the
TNF that drives ICAM-1 and CINC expression is
derived largely from alveolar macrophages rather than PMNs
Ikeda et al., J Cardiovasc Pharmacol 1994
:
In ELISA analysis,
ICAM-1 molecule expression on myocytes was significantly
stimulated by
TNF-alpha ( 100 U/ml ), but not by IL-6 ( 100 U/ml ) or IL-8 ( 100 ng/ml ) dose dependently
Groves et al., Br J Dermatol 1995
(Dermatitis...) :
TNF-alpha induced endothelial E-selectin,
intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in all groups, and adhesion molecule expression by interstitial dermal dendritic cells ( ICAM-1 and VCAM-1 ) and keratinocytes ( ICAM-1 ) was observed
Ferran et al., Biochem Biophys Res Commun 1995
:
We show that pyrrolidine dithiocarbamate strongly reduces the
TNF alpha mediated induction of E-selectin, VCAM-1,
ICAM-1 , PAI-1, tissue factor, IL-8 and I kappa B-alpha
Chen et al., J Immunol 1995
:
In contrast, the
TNF-alpha induced expression of plasminogen activator inhibitor-1 and the constitutive expression of
ICAM-2 were unaffected
Hauser et al., J Immunol 1993
:
Venous and arterial large vessel endothelial cells ( EC ) were compared for their constitutive and
TNF-alpha induced expression of the cell-surface adhesion molecules
ICAM-1 and -2 , VCAM-1 and ELAM-1 by FACS analysis ...
TNF-alpha increases the expression of ICAM-1, but not
ICAM-2 , and induces the expression of ELAM-1 on both EC types
Goebeler et al., Immunobiology 1993
(Inflammation) :
Furthermore,
ICAM-1 expression by bone marrow derived M phi could be
up-regulated by
tumor necrosis factor-alpha , interferon-gamma and LPS
Ford et al., J Surg Res 1996
:
Labeling had no effect on EC proliferation rates nor on
TNF induced upregulation of
ICAM expression
Syrbu et al., Exp Lung Res 1996
(Disease Models, Animal...) :
The time courses for
ICAM and ELAM
stimulation with pure
TNF alpha or BALF60 containing equivalent levels of TNF alpha were the same
Klein et al., Pathobiology 1995
:
Thus,
ICAM-1 increased dramatically after 5 h incubation with
TNF-alpha
Gille et al., J Clin Invest 1997
(Inflammation) :
To determine modes of retinoid action in the modulation of inflammatory responses, we explored effects of all-trans-retinoic acid ( t-RA ) on the
TNFalpha induced expression of vascular cell adhesion molecule-1 ( VCAM-1 ),
intercellular adhesion molecule-1 ( ICAM-1 ), and E-selectin in cultured human dermal microvascular endothelial cells
Fujisawa et al., J Dermatol Sci 1997
(Carcinoma, Squamous Cell) :
This evidence contrasts with previously reported findings indicating that, in human cultured keratinocytes,
ICAM-1 expression is
induced by IFN-gamma and
TNF-alpha , and not by either IL-1 or LPS
Jiang et al., Neurochem Int 1997
:
Since adhesion molecules ( AM ) induced on endothelial cells ( EC ) play an important role in T-cell migration into the CNS, the objective of this study was to examine the effect of IFN beta-1b on the expression of the AM,
ICAM-1 , V-CAM and E-selection
induced on EC by IFN-gamma,
TNF-alpha , or IL-1 beta
Shen et al., J Virol 1997
:
TNF-alpha significantly
enhanced WNV induced increases in E-selectin, P-selectin,
ICAM-1 , and VCAM-1 expression, while IFN-gamma enhanced WNV induced ICAM-1 expression
Braun et al., Arterioscler Thromb Vasc Biol 1997
(Second Messenger Systems) :
In cultured human smooth muscle cells from coronary arteries and saphenous veins,
tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta)
induced the expression of
intercellular adhesion molecule ( ICAM-1 ) and vascular cell adhesion molecule ( VCAM-1 ), whereas interferon-gamma (INF-gamma) selectively stimulated the expression of ICAM-1
Takeshita et al., Infect Immun 1998
:
In addition,
ICAM-1 clearly
inhibited the fimbria induced expression of IL-1beta and
TNF-alpha genes in the cells
Chatterjee et al., Arterioscler Thromb Vasc Biol 1998
(Arteriosclerosis) :
Additional studies have revealed that LacCer mediates the
tumor necrosis factor-alpha (TNF-alpha) induced nuclear factor-kappaB expression and
intercellular adhesion molecule ( ICAM-1 ) expression in vascular endothelial cells via the redox dependent transcriptional pathway
Lakshminarayanan et al., J Biol Chem 1998
:
We previously demonstrated that
tumor necrosis factor-alpha (TNFalpha) and H2O2 differentially
regulate interleukin-8 (IL-8) and
intercellular adhesion molecule ( ICAM-1 ) gene expression in endothelial and epithelial cells