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NFKB1 — TNFRSF8
Text-mined interactions from Literome
Horie et al., Am J Pathol 1999
(Leukemia, Lymphoid...) :
CD30v can
activate the
nuclear factor-kappaB (NF-kappaB) as CD30, and its overexpression in HL-60 induced a differentiated phenotype
Horie et al., Oncogene 2002
(Hodgkin Disease) :
We report that in H-RS cells overexpression of
CD30 leads to self-aggregation, recruitment of TRAF2 and TRAF5, and
NF-kappaB activation, independent of CD30 ligand
Higuchi et al., Retrovirology 2005
(Leukemia-Lymphoma, Adult T-Cell) :
Exogenous stable expression of
CD30 in Rat-1 cells constitutively
activated NF-kappaB
Uchihara et al., Int J Cancer 2006
(Hodgkin Disease) :
Thus, in H/RS cells, ligand independent activation of
CD30 signalling
activates NF-kappaB and this leads to constitutive ICAM-1 expression, suggesting a link between 2 well known phenotypic characteristics of HL, CD30 and ICAM-1 overexpression
Poppema et al., Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005
(Hodgkin Disease) :
A key role is played by the presence of constitutive nuclear factor
(NF)-kappaB , which is
induced by LMP1, as well as by
CD30 , CD40, tumor necrosis factor (TNF)-alpha, and Notch1 interactions, and results in the upregulation of at least 45 genes including chemokines, cytokines, receptors, apoptotic regulators, intracellular signaling molecules, and transcription factors
Guo et al., Mol Immunol 2009
(Hodgkin Disease) :
Importantly, the
CD30 induced alternative
NF-kappaB activation is inhibited by the depletion of the TRAF1 expression
Abdulamir et al., J Investig Allergol Clin Immunol 2009
(Asthma) :
NF-kappaB seems to be the central inflammatory factor in SA, with a remarkable loss of PBL apoptosis, diminished Treg levels, and high
CD30+ cell levels that probably
induce NF-kappaB , which in turn blocks the proapoptotic potential of CD30 induction itself
Biswas et al., Immunity 1995
:
Furthermore, cross linking of
CD30 leads to
NF-kappa B activation and enhanced HIV transcription
McDonald et al., Eur J Immunol 1995
(Hodgkin Disease...) :
Moreover, in human T helper ( Th ) clones functionally characterized as being of the type 0, type 1 and type 2 ( 28 %, < 1 % und 93 % CD30+, respectively ), the extent of
CD30 mediated
NF-kappa B activation correlated with the proportion of CD30+ cells
Lee et al., Proc Natl Acad Sci U S A 1996
:
We demonstrate here that TRAF2 also plays an important role in
CD30 induced
NF-kappa B activation
Aizawa et al., Gene 1996
:
Transient overexpression of rat CD30 in TARL-2 cells activated HIV LTR in a NF-kappa B site dependent manner, indicating that
CD30 signals
activate NF-kappa B
Aizawa et al., J Biol Chem 1997
:
Tumor necrosis factor receptor associated factor ( TRAF) 5 and TRAF2 are involved in
CD30 mediated
NFkappaB activation ... Overexpression of the TRAF domain of TRAF2 or TRAF5 showed a dominant negative effect on
CD30 mediated
NFkappaB activation ... Taken together, our results indicate that TRAF2 and TRAF5 directly interact with CD30 and are involved in
NFkappaB activation by
CD30 signaling
Duckett et al., Mol Cell Biol 1997
:
Together, these data support a model in which
CD30 can
induce NF-kappaB by both TRAF dependent and -independent mechanisms
Tsitsikov et al., Proc Natl Acad Sci U S A 1997
:
Moreover, dominant negative mutants consisting of the TRAF domain of TRAF1 and TRAF2 inhibited
CD30 induction of
NF-kappaB activation and HIV-1 transcription
Horie et al., Int Immunol 1998
:
Activation of
NFkappaB by
CD30 was shown to be mediated through interaction of TNFR associated factor (TRAF) 1, 2 and 5 with the D2 and D3 subdomains ... Electrophoretic mobility shift assays revealed constitutive and
CD30 induced
NFkappaB activation in stable transformants of 293 cells expressing CD30 or a deletion mutant lacking D2 and D3 subdomains