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JUN — MMP3

Text-mined interactions from Literome

Westermarck et al., FASEB J 1999 (Neoplasm Invasiveness...) : This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the role of mitogen activated protein kinases and AP-1 and ETS transcription factors in the regulation of MMP gene expression during invasion process
Sato et al., Cancer Res 2002 (Fibrosarcoma...) : These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin mediated inhibition of activator protein-1 binding activity is at least partly involved in the suppression of MMP expression
Bamba et al., J Gastroenterol 2003 : There findings indicate a role for AP-1 and MAP kinases in cytokine induced MMP-3 secretion
Fleenor et al., Invest Ophthalmol Vis Sci 2003 : Involvement of AP-1 in interleukin-1alpha stimulated MMP-3 expression in human trabecular meshwork cells
Pang et al., Invest Ophthalmol Vis Sci 2003 (Glaucoma, Open-Angle) : These effects were blocked by sequestering AP-1, suggesting that activation of AP-1 can lead to increased MMP-3 production in the TM, which in turn improves outflow facility
Kondo et al., Int J Cancer 2005 (Carcinoma, Squamous Cell...) : LMP1 transfected cells with 2G/2G genotype expressed MMP1, which was abolished by activator protein-1 (AP1) dominant negative ( DN ) and Ets-DN. LMP1 also induced active MMP3 , which can cleave latent MMP1, and AP1-DN and Ets-DN suppressed the MMP3 expression
Kajanne et al., J Cell Physiol 2007 : Here we provide genetic and biochemical evidence that EGF-R- and AP-1 mediated signals are required for MMP expression and collagen contraction in fibroblasts
Hammaker et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : c-Jun N-terminal kinase (JNK) contributes to metalloproteinase ( MMP ) gene expression and joint destruction in inflammatory arthritis
Oliver et al., J Rheumatol 2007 (Arthritis, Experimental...) : We evaluated whether a vanadium AP-1 inhibitor could reduce MMP expression and subsequent joint damage in CIA
Lin et al., Rheumatol Int 2008 (Chondrosarcoma...) : Using chondrosarcoma cells stimulated with IL-1beta, the effects of GLN on the mRNA and protein levels of MMP-3 , the activation of JNK, ERK, p38, NF-kappaB, and AP-1 , the nuclear translocation of NF-kappaB/Rel family members, and PI3-kinase/Akt activation were studied
Woo et al., J Neurochem 2008 : Inhibition of MMP-3 or -9 significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-kappaB, AP-1 , and MAPK in LPS stimulated microglia
Meng et al., Toxicol Lett 2009 : Mechanistic studies indicate that B [ a ] P-induced transcriptional activation of MMP-3 is not mediated by AP-1 , NF-kappaB
Green et al., J Immunol 2010 (Tuberculosis, Central Nervous System) : Chemical inhibition and promoter-reporter analyses showed that NF-kappaB and AP-1 c-Jun/FosB heterodimers regulate CoMTb induced MMP-1/-3 secretion
Lee et al., J Immunol 2010 : Inhibition of MMP-3 or -9 also suppressed the activities of MAPK, NF-kappaB, and AP-1
Chan et al., International journal of molecular sciences 2011 : In the current study, pretreatment with nitric oxide ( NO ) scavengers inhibited PDT induced mitochondrial membrane potential ( MMP ) changes, activation of caspase-9, caspase-3, p21 activated protein kinase 2 (PAK2) and c-Jun N-terminal kinase (JNK) , and gene expression of p53 and p21 involved in apoptotic signaling
Lee et al., J Dermatol Sci 2013 : In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen activated protein kinase ( MAPK ), ATF-2, and c-Jun , and MMP expression
Chambers et al., Exp Cell Res 2013 (Periodontitis) : Here we show that IL-1 induced binding of transcription factor AP-1 to the MMP-3 promoter consists primarily of c-Jun, JunB, and c-Fos and that binding of c-Jun and c-Fos is inhibited by the combination of cytokines while binding of Jun B is not