Gene interactions and pathways from curated databases and text-mining

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CCDC88A — EPHB2

Text-mined interactions from Literome

Lee et al., J Immunol 2009 (Inflammation...) : Silencing of APE1 attenuated cyclin D1/cyclin dependent kinase 4 expression and phosphorylation of ERK1/2 and Akt, thereby affecting keratinocyte proliferation
Wang et al., Toxicology 2013 : Here, we explore whether APE1 and reactive oxygen species ( ROS ) affect ERK signaling and cell cycle progression following Pb exposure ... Intriguingly, the capability of Pb to activate ERK was abolished under siAPE1 or E3330 co-treatments ; conversely, forced expression of APE1 up-regulated the ERK activation by Pb or serum in both Cys65-redox activity dependent and independent manners