Wang et al., Cancer Lett 2010
(Ovarian Neoplasms) :
Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2, Bcl-xL and XIAP ), as well as activation of Ras/MEK/ERK and PI3K/Akt signaling
Ahn et al., Biochem Biophys Res Commun 2010
:
Taken together, our results demonstrate that XIAP plays a key role in shear stress stimulated ERK activation by maintaining the Src-accessible location of FAK
Yuan et al., Biochem Biophys Res Commun 2012
(MAP Kinase Signaling System) :
The activation of ERK increased XIAP expression and led to decreased caspase activation