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TNF — VDR
Text-mined interactions from Literome
Stio et al., Int Immunopharmacol 2005
:
VDR protein levels were
increased by 0.1 nM KH 1060, 0.1 microg/ml
anti-TNF or their combination
Saito et al., American journal of physiology. Renal physiology 2010
:
In the present investigation, we identified that
TNF-alpha selectively
represses activity of RAR but not
VDR
Barrera et al., Cytokine 2012
(Inflammation...) :
This effect is mediated by the
VDR and might
involve direct inhibition of
TNF-a
Xiong et al., American journal of physiology. Renal physiology 2012
(Inflammation...) :
In cultured proximal tubular epithelial HK-2 cells, proinflammatory
TNF-a inhibited the expression of
VDR in a dose- and time-dependant manner ... These results indicate that the early loss of
VDR in chronic kidney diseases was likely
mediated by proinflammatory
TNF-a , which renders tubular cells susceptible to EMT
Gupta et al., PloS one 2012
(Atherosclerosis...) :
Effect of
TNF-a-stimulation on the activity and expression of
VDR was analyzed by luciferase assay, immunoblotting and immunocytochemistry
Harant et al., Eur J Biochem 1997
:
Furthermore, overexpression of
VDR in the parental G-361 cell line
enhanced the repressive effect of calcitriol on activation of the IL-8 promoter by either
TNF-alpha stimulation or overexpression of the NF-kappaB subunit p65
Fernandez-Martin et al., Mol Cell Endocrinol 1998
:
Here we test the hypothesis that
TNF induces a nuclear inhibitor of
RXR/VDR binding to DNA and that this inhibitor can have independent effects on RXR ... The
effect of
TNF on RXR and
VDR binding to their cognate response elements and stimulation of transcription was studied in VDR deficient CV-1 and COS-7 cells ... To determine if
TNF-alpha induced a nuclear inhibitor of
VDR and RXR binding to DNA, nuclear extract was isolated from TNF treated receptor deficient COS cells and mixed with nuclear extract from ligand treated receptor replete COS cells ... We conclude that
TNF activates a nuclear inhibitor of
VDR and RXR