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TNF — WNT10B
Text-mined interactions from Literome
Saitoh et al., Int J Oncol 2001
(Stomach Neoplasms) :
Because interferon gamma (IFNgamma) and TNFalpha were frequently elevated in gastric mucosa with Helicobacter pylori infection,
effects of IFNgamma and
TNFalpha on
WNT10B expression in MKN45 cells were investigated
Kirikoshi et al., Int J Mol Med 2002
(Breast Neoplasms...) :
Human
WNT10B is moderately expressed in MKN45 and MKN74 cells derived from human gastric cancer, and is
up-regulated by
tumor necrosis factor alpha (TNFalpha) in MKN45 cells
Gustafson et al., J Biol Chem 2006
(Diabetes Mellitus...) :
TNFalpha , but not IL-6,
activated Wnt10b expression, whereas IL-6 increased the apparent phosphorylation of Dishevelled
Katoh et al., Int J Mol Med 2007
(Cell Transformation, Neoplastic) :
In 2001, we reported
WNT10B upregulation by
TNFalpha ... Because TNFalpha signaling through TNFR1 and TRADD/RIP/TRAF2 complex activates JUN kinase (JNK) and IkappaB kinase (IKK) signaling cascades, conserved AP1- and NF-kappaB binding sites explain the mechanism of
TNFalpha induced
WNT10B upregulation
Katoh et al., Cancer Biol Ther 2007
(Helicobacter Infections...) :
IL-6 and
TNFalpha induce upregulation of WNT5A and
WNT10B , respectively
Isakson et al., Diabetes 2009
(Inflammation...) :
TNF-alpha , but not IL-6 or resistin,
increased Wnt10b , completely inhibited the normal differentiation of the preadipocytes, and instead induced a proinflammatory and macrophage-like phenotype of the cells
Briolay et al., Biochem Biophys Res Commun 2013
(Spondylitis, Ankylosing) :
In human mesenchymal stem cells ( MSCs ),
TNF-a significantly
increased the levels of
Wnt10b and Wnt5a